Effect of delta sleep-inducing peptide on catalytic properties of mitochondrial malate dehydrogenase from rat brain

Delta sleep-inducing peptide is shown to alter properties of malate dehydrogenase in brain mitochondria. The regulatory activity of the peptide is manifested in stabilization of catalytic properties of the enzyme at a higher level, which prevents their change during hypoxic stress. Regulation of malate dehydrogenase is presumed to occur through direct action of the peptide on mitochondrial membranes. Translated fromByulleten Eksperimental'noi Biologii i Meditsiny, Vol. 119, No. 2, pp. 141–143, February, 1995 Presented by I. P. Ashmarin, Member of the Russian Academy of Medical Sciences