Association of visceral and subcutaneous fat with glucose intolerance, insulin resistance, adipocytokines and inflammatory markers in Asian Indians (CURES-113) |
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Authors: | Indulekha Karunakaran Anjana Ranjith Mohan Surendar Jayagopi Mohan Viswanathan |
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Affiliation: | aMadras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control, International Diabetes Federation (IDF) Centre for Education, Gopalapuram, Chennai, 600 086, India |
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Abstract: | Objectives:The aim of the study was to assess the association between visceral and subcutaneous fat with glucose intolerance, adipocytokines, inflammatory markers and carotid IMT in Asian Indians.Design and methods:Subjects with NGT (n = 85), IGT (n = 49) and T2DM (n = 93) were randomly selected from CURES. Total abdominal, visceral and subcutaneous fat were measured using Helical CT scan. Adiponectin, hs-CRP, TNF-alpha, oxidized LDL, visfatin and leptin and IMT and insulin resistance were assessed.Results:Total abdominal fat (p = 0.041) and the visceral fat (p = 0.039) but not subcutaneous fat progressively increased from NGT, IGT and T2DM subjects. With increasing quartiles of visceral fat, there was a significant increase in insulin resistance (p = 0.040); significant decrease in adiponectin (p = 0.043) and increase in TNF-alpha (p = 0.028), hs-CRP (p = 0.043), OX-LDL (p = 0.034) and visfatin (p = 0.040), and carotid IMT (p = 0.047) was observed.Conclusion:Visceral fat levels increased with increasing glucose intolerance and are associated with decreased levels of adiponectin and increased levels of hs-CRP, TNF-alpha, oxidized LDL, visfatin, HOMA-IR and IMT. |
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Keywords: | Abbreviations: NGT, normal glucose tolerance IGT, impaired glucose tolerance T2DM, type 2 diabetes mellitus CAD, coronary artery disease CURES, Chennai Urban Rural Epidemiology Study HOMA-IR, homeostasis model assessment of insulin resistance IMT, intimal media thickness CT, computed tomography TNF-alpha, tumor necrosis factor alpha Oxidized LDL, oxidized low density lipoproptein ELISA, enzyme-linked immunosorbent assay hs-CRP, high sensitive C-reactive protein BMI, body mass index FPG, fasting plasma glucose WHO, World Health Organization ANOVA, analysis of variance FFA, free fatty acid SECURE, Study to Evaluate Carotid Ultrasound changes in patients treated with Ramipril and vitamin E GRACE study, Gender, Race and Clinical Experience study HDL-C, high density lipoprotein cholesterol LDL-C, low density lipoprotein cholesterol HbA1c, glycosylated hemoglobin SPSS, Statistical Package for Social Sciences SD, standard deviation IRS, insulin receptor substrate TG, triglyceride IR, insulin resistance PIVUS, Prospective Study of the Vasculature in Uppsala Seniors |
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