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Effects of crude drugs on experimental hypercholesterolemia. I. Tea and its active principles
Authors:H Matsuda  T Chisaka  Y Kubomura  J Yamahara  T Sawada  H Fujimura  H Kimura
Affiliation:1. Kyoto Pharmaceutical University, 5 Misasagi Nakauchi-cho, Yamashina-ku, Kyoto 607 Japan;1. Gifu University School of Medicine, 40 Tsukasamachi, Gifu 500 Japan;1. Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY 14642, United States;2. Department of Chemistry, University of Rochester, Rochester, NY 14642, United States;3. Department of Dermatology, University of Rochester, Rochester, NY 14642, United States;4. Department of Biostatistics, University of Rochester, Rochester, NY 14642, United States;5. Department of Biostatistics and Data Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, United States;1. Laboratory of Natural Products Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon;2. Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan;3. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan;1. Department of Chemical Sciences, University of Padua, Via Marzolo, 1, 35131 Padova, Italy;2. Estación Experimental Agropecuaria Famaillá, Instituto Nacional de Tecnología Agropecuaria, Ruta provincial 301, km 32, Famaillá, Tucumán, Argentina;1. Cardiac and Cerebral Vascular Research Center, Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China;2. Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China;3. Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China;1. Dipartimento Di Farmacia, Università “G. d’Annunzio” Chieti - Pescara, Via Dei Vestini 31, 66100 Chieti Scalo, CH, Italy;2. Prolabin & Tefarm Srl, Via dell’Acciaio 9, 06134 Perugia, Italy
Abstract:The effect of methanol extractives from tea leaves on hypercholesterolemia was examined in animal models. It was found that orally administered (-)-epicatechin gallate and (-)-epigallocatechin gallate from tea leaves lowered the serum cholesterol level in mice fed a high fat emulsion. Quantitation of tissue cholesterol and examination of liver tissues in mice fed a high cholesterol diet revealed that these constituents also significantly lowered the amount of cholesterol crystallization. These results support the reputed effectiveness of tea use in hypercholesterolemia.
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