|
|||||
|
|
| 胰岛细胞抗体与胰岛β细胞功能关系的探讨 | |
| 引用本文： | 张爱芳,董维平,彭永德,王非,顾丽萍. 胰岛细胞抗体与胰岛β细胞功能关系的探讨[J]. 中华糖尿病杂志, 2008, 16(11): 674-675 |
| 作者姓名： | 张爱芳 董维平 彭永德 王非 顾丽萍 |
| 作者单位： | 上海交通大学附属第一人民医院内分泌科糖尿病研究室,200080 |
| 摘 要： | 对251例1型糖尿病（T1DM）患者进行胰岛细胞抗体（ICA）检测,发现ICA阳性组中谷氨酸脱羧酶抗体（GADA）和蛋白酪氨酸磷酸酶抗体（IA-2A）阳性率均显著高于ICA阴性组（P〈0.01）,空腹和餐后胰岛素水平明显低于ICA阴性组（P〈0.05,P〈0.01）,胰岛素抵抗指数亦明显下降（P〈0.05）,提示T1DM患者中ICA阳性更易于合并有GADA、1A-2A阳性,且对胰岛β细胞功能的破坏更大。 |
| 关 键 词： | 胰岛细胞抗体 胰岛素抵抗 糖尿病,1型 |
Association of pancreatic β-cell auto-antibody and islet beta-cell function |
|
| ZHANG Ai-fang,DONG Wei-ping,PENG Yong-de,et al.. Association of pancreatic β-cell auto-antibody and islet beta-cell function[J]. CHINESE JOURNAL OF DIABETES MELLITUS, 2008, 16(11): 674-675 | |
| Authors: | ZHANG Ai-fang DONG Wei-ping PENG Yong-de et al. |
| Affiliation: | ZHANG Ai-fang,DONG Wei-ping,PENG Yong-de,et al.Department of Endocrinology , Diabetic Research Laboratory,Shanghai Jiaotong University-affiliated First People's Hospital,Shanghai 200080,China |
| Abstract: | 251 patients with type 1 diabetes were collected to detect the level of islet cell antibody(ICA).The positive rates of GADA and IA-2A were higher in ICA positive group than in ICA negative group(P<0.01).While fasting and postprandial insulin levels were much lower in ICA positive group than in ICA negative group(P<0.05 or P<0.01).According to the increased insulin resistance index and reduced insulin sensitivity index in ICA negative group(P<0.05),islets with negative ICA may have less impairment and may se... |
| Keywords: | Islet cell antibody Insulin resistance Diabetes mellitus type 1 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |