New Antitrypanosomal Tetranotriterpenoids from Azadirachta Indica |
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| Authors: | Mercy Githua Ahmed Hassanali Joseph Keriko Grace Murilla Mary Ndungu Gathu Nyagah |
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| Affiliation: | 1Department of Chemistry, Jomo Kenyatta University of Agriculture and Technology (JKUAT), P.O Box 62000-00200 Nairobi, Kenya;2International Center of Insect Physiology and Ecology (ICIPE), P.O Box 30772, Nairobi, Kenya;3Trypanosomiasis Research Center (TRC), P.O Box 362, Kikuyu, Kenya |
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| Abstract: | Organic extracts of the leaves of Azadirachta indica A. Juss. yielded ten antitrypanosomal terpenoids. Three of these (1 – 3), are novel and are derivatives of nimbolide and nimbin. They were extracted from chloroform fraction of methanol extract. These compounds were found to exhibit strong antitrypanosomal activities against Trypanosoma brucei rhodesiense with MIC values ranging of 6.9, 15.6 and 7.8 µg/ml respectively and were more active than Cymerlarsan ( a standard drug), which had an MIC value of 187.5 µg/ml when tested against T. b. rhodesiense The structures were elucidated by spectroscopic methods including; NMR, MS, UV and IR. |
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| Keywords: | Meliaceae limonoids Trypanosoma brucei rhodesiense Azadirachta indica antitrypanosomal activity |
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