| 血管肌纤维母细胞瘤临床病理学观察 |
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| 引用本文： | 郜红艺,赖日权,张佳立,吴坤河,张江宇.血管肌纤维母细胞瘤临床病理学观察[J].临床与实验病理学杂志,2008,24(5). |
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| 作者姓名： | 郜红艺 赖日权 张佳立 吴坤河 张江宇 |
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| 作者单位： | 1. 广东省妇幼保健院,病理科,广州,510010
2. 广州军区总医院病理科,广州,510010 |
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| 摘 要： | 目的 探讨血管肌纤维母细胞瘤( angiomyfibroblastoma, AMF )的临床病理特点及其诊断与鉴别诊断.方法 通过对7例AMF的临床表现、组织学观察与免疫组化研究,并复习相关文献总结AMF的临床病理特征及鉴别诊断.结果 7例均为女性,年龄25～52岁,部位在大阴唇(3例)、宫颈管(3例)和腹股沟(1例),大小1.6～6.0 cm;眼观:肿瘤边界清,无包膜,质地韧,切面灰白,局部有黏液感.镜检:肿瘤细胞分布稀疏不一,呈密集的血管区与少细胞的水肿区相交替分布.瘤细胞肥胖,呈梭形或短梭形,可见胞质突起或波浪状弯曲,瘤细胞围绕丰富的血管,大多是薄壁小血管或毛细血管,间质可见胶原束.免疫表型:瘤细胞vimentin和desmin弥漫阳性,α-SMA和CD34局灶阳性,发生于宫颈的3例ER和PR弱阳性,所有病例CK、S-100蛋白阴性.结论 AMF是发生女性外阴、生殖道的良性软组织肿瘤;需要与侵袭性血管黏液瘤、富于细胞性的血管纤维瘤、青春期前外阴纤维瘤、浅表宫颈阴道肌纤维母细胞瘤等软组织肿瘤相鉴别.
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| 关 键 词： | 血管肌纤维母细胞瘤 病理学 临床 鉴别诊断 |
Clinicopathological features and differential diagnosis of angiomyofibroblastoma |
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| GAO Hong-yi,LAI Ri-quan,ZHANG Jia-li,WU Kun-he,ZHANG Jiang-yu.Clinicopathological features and differential diagnosis of angiomyofibroblastoma[J].Chinese Journal of Clinical and Experimental Pathology,2008,24(5). |
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| Authors: | GAO Hong-yi LAI Ri-quan ZHANG Jia-li WU Kun-he ZHANG Jiang-yu |
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| Institution: | 1Department of Pathology;Guangdong Provincial Women and Children's Hospital;Guangzhou 510010;2Department of Pathology;General Hospital of Guangzhou Command;China |
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| Abstract: | Purpose To investigate the clinicopathological characteristics and differential diagnosis of angiomyofibroblastoma(AMF).Methods Seven cases of AMFs were analyzed by gross examination,light microscopy and immunohistochemistry.Relevant literatures were reviewed to summarize the diagnostic features of AMF and its differential diagnosis.Results All the 7 cases were females aged from 25 to 52 years.3 cases were located in labia majora,3 in cervix,and 1 in inguinal region.Tumors were all well circumscribed but un... |
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| Keywords: | angiomyfibroblastoma pathology clinical differential diagnoses |
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