托吡酯治疗儿童癫癎出现泌汗障碍的临床观察与随访

目的研究托吡酯治疗儿童癫癎时出现的泌汗障碍(少汗或无汗)及其对策.方法通过追踪随访了解泌汗障碍与托吡酯服用的时间、季节、剂量、加药速度等的关系,合用其他抗癫癎药的影响,以及出现泌汗障碍后的转归.结果泌汗障碍与托吡酯服用的时间、剂量、加药速度无相关性,不同患儿间存在很大差异,不受合并用药的影响,高温时节症状明显,减缓加药速度可增加易感患儿对泌汗障碍的耐受性.结论托吡酯治疗儿童癫癎时出现的泌汗障碍为托吡酯所致,停药后泌汗功能恢复正常,大部分患儿对其耐受性好,泌汗障碍为非器质性损伤.

Clinical observation and follow-up of children with perspiration disorder in the course of treating epilepsy by topiramate

Objective To study perspiration disorder(hyporidrosis or adiaphoresis) in the course of treating epilepsy by topiramate(TPM) in children and the countermeasures.Methods The relationship of perspiration disorder(PD) with time,season,dosage,speed of increasing dosage of TPM,influence of other antiepileptic drugs used at the same time and prognosis after PD occurs was studied.Results PD was not related to time,dosage and speed of increasing dosage of TPM.There were differences in different patients.Moreover,other antiepileptic drugs had no effect on PD caused by TPM.In the high temperature season,PD was more obvious.To slow the speed of increasing dosage could improve the durability to PD of susceptible patients.Conclusion The PD which occurs in the course of treating epilepsy by TPM is caused by TPM itself,and perspiring function can return to normal after stopping using TPM.Most patients have durability to PD.