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| 肾康注射液与苯那普利对肾小球系膜基质作用的对比研究 | |
| 引用本文： | 郭立中,刘玉宁,毛炜,叶传蕙,顾云,周姗姗. 肾康注射液与苯那普利对肾小球系膜基质作用的对比研究[J]. 中国中西医结合杂志, 2000, 20(1): 50-52 |
| 作者姓名： | 郭立中 刘玉宁 毛炜 叶传蕙 顾云 周姗姗 |
| 作者单位： | 南京中医药大学博士后流动站!南京210029(郭立中，顾云)，成都中医药大学(刘玉宁，叶传蕙)，广东省中医院(毛炜)，武警南京医院(周姗姗) |
| 基金项目： | 国家中医药管理局资助! (No.92DO89) |
| 摘 要： | 目的 探讨肾康注射液与苯为利对人肾小球系膜细胞外基质（ＥＣＭ）不同成分的抑制作用强度。方法 采用体外培养的人肾小球系膜细胞技术，观察具有降逆泄浊、益气活血功效的中药肾康注射液及苯那普利时ＥＣＭ不同成分的影响。结果 肾康注射液具有抑制ＥＣＭ成分中纤维连接蛋白（ＦＮ）、层粘连蛋白（ＬＮ）和Ⅳ型胶原（ＣｏｌⅣ）的作用，该抑制作用具有一定的量效关系。苯那普利对ＥＣＭ中ＦＮ、ＣｏｌⅣ也有一定的抑制作用，但不 |
| 关 键 词： | 肾康注射液 苯那普利 细胞外基质 肾小球系膜 |
Contrast Study on Effect of Shenkang Injection and Benazepril on Human Glomerular Mesangial Extracellular Matrix |
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| GUO Lizhong,LIU Yuning,MAO Wei,et al Nanjing University of TCM,Nanjing. Contrast Study on Effect of Shenkang Injection and Benazepril on Human Glomerular Mesangial Extracellular Matrix[J]. Chinese journal of integrated traditional and Western medicine, 2000, 20(1): 50-52 | |
| Authors: | GUO Lizhong LIU Yuning MAO Wei et al Nanjing University of TCM Nanjing |
| Abstract: | OBJECTIVE: To explore the intensity of inhibition of Shenkang Injection (SKI) and Benazepril on various ingredients of human glomerular mesangial extracellular matrix (ECM). METHODS: Effect of SKI, a herbal preparation for lowering adverse Qi, despelling turbidness, supplementing Qi and activating circulation, and Benazepril were observed by cultured glomerular mesangial cell technique in vitro. RESULTS: SKI could inhibit the fibronetin, laminin, and type IV collagen of ECM, and the action was dose-dependent. Benazepril could also inhibit the fibronetin and type IV collagen of ECM but was weaker in intensity. CONCLUSION: The effect of SKI was superior to Benazepril in inhibiting ECM. |
| Keywords: | Shenkang Injection Benazepril mesangial cell extracellular matrix |
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