维持恒定SEF普鲁卡因对七氟醚呼末浓度的影响

目的应用七氟醚～氧化亚氮－氧气维持SEF9～11Hz一段时间后，静滴普鲁卡因观察维持SEF恒定所需七氟醚呼末浓度的变化。方法8例ASAⅠ～Ⅱ级行择期非开胸手术病人，诱导气管插管后，调整呼末七氟醚浓度使SEF降至9～11Hz，并维持此水平1h后，以1mg

The influence ofintravenous procaine infusion to end-tidal sevoflurane concentration during hold constantSEF

Objective:To examine the changes of end-tidal sevoflurane concentration to hold a constant EEG spectral edge frequence(SEF9－11 Hz) during continuous procaine infusion.Methods:Eight patients,ASA Ⅰ～Ⅱ，scheduled for no-thoracic operations were included.After intubation,end-tidal sevoflurane concentrations were regulated so that SEF was held between 9 and 11 Hz for at least 1 hour,then 1％ procaine was infused intravenously at a rate of 1mg*kg－1*min－1.After continuous procaine infusion for 30 min,end-tidal sevoflurane concentrations were again regulaed so as to hold constant SEF between 9 and 11 Hz. Results:End-tidal sevoflurane concentrations to hold SEF between 9 and 11 Hz were 1.62％±0.04％ before intravenous procaine infusion and were 1.32％±0.07％，reduced about 20％，after intravenous procaine infusion for 30 min.Conclusion:The inhibitive effect of procaine to brain is weak in clinical common doses.