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Early response monitoring in malignant lymphoma using fluorine-18 fluorodeoxyglucose single-photon emission tomography
Authors:Otto S. Hoekstra  Arthur van Lingen  Gert J. Ossenkoppele  Richard Golding  Gerrit J.J. Teule
Affiliation:(1) Department of Nuclear Medicine, Free University Hospital, Amsterdam, The Netherlands;(2) Department of Haematology, Free University Hospital, Amsterdam, The Netherlands;(3) Department of Radiology, Free University Hospital, Amsterdam, The Netherlands;(4) Department of Nuclear Medicine, Free University Hospital, De Boelelaan 1117, NL-1081 HV Amsterdam, The Netherlands
Abstract:Metabolic response monitoring early during chemotherapy may have a major impact on clinical management of patients with malignant lymphoma. In two patients with non-Hodgkin's lymphoma fluorine-18 fluorodeoxyglucose (IgFDG) single-photon emission tomography (SPET) studies were performed during the first two chemotherapeutic cycles. Persisting uptake predicted treatment failure whereas a sharp reduction of 18FDG uptake was demonstrated in the case of a responsive tumour. Qualitative analysis of conventional 18FDG imaging may thus serve to identify patients with a non-responding tumour. The potential of this technique in the determination of the initial response remains to be established. Imaging with 18FDG and SPET appears promising as a more easily available methodology than 18FDG positron emission tomography.
Keywords:Single-photon emission tomography  Fluorine-18 fluorodeoxyglucose  Chemotherapy  Response monitoring  Malignant lymphoma
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