HLA-B*35-Restricted CD8+-T-Cell Epitope in Mycobacterium tuberculosis Rv2903c |
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| Authors: | Mich l R. Klein, Abdulrahman S. Hammond, Steve M. Smith, Assan Jaye, Pauline T. Lukey, Keith P. W. J. McAdam |
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| Affiliation: | TB Research Programme, MRC Laboratories, Fajara, The Gambia. petiet@stanford.edu |
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| Abstract: | Few human CD8(+) T-cell epitopes in mycobacterial antigens have been described to date. Here we have identified a novel HLA-B*35-restricted CD8(+) T-cell epitope in Mycobacterium tuberculosis Rv2903c based on a reverse immunogenetics approach. Peptide-specific CD8 T cells were able to kill M. tuberculosis-infected macrophages and produce gamma interferon and tumor necrosis factor alpha. |
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