成都地区非酒精性脂肪肝与代谢综合征相关性研究

目的调查分析非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)和代谢综合征(metabolic syndrome,MS)的关系。方法采集2011年2～5月成都地区在四川大学华西医院进行健康检查的20～80岁受检者的疾病史、体格检查、生化检测以及上腹部超声检查的结果,并对数据进行统计分析。结果 NAFLD患病率12.33%,NAFLD、MS两病的共患病率3.47%。NAFLD、MS两病共患病率随体重指数(BMI)增加而升高。单纯NAFLD组BMI、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、甘油三酯(TG)、低密度脂蛋白(LDL-C)均高于正常组(P﹤0.01),高密度脂蛋白(HDL-C)低于正常组(P﹤0.01);NAFLD合并MS组丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、谷氨酰转肽酶(GGT)均高于单纯组(P﹤0.01)。结论 NAFLD与MS紧密相关,二者发病过程中的相互加重、相互促进作用应当引起足够的重视并应进行综合防治。

Study on the relevant study between non-alcoholic fatty liver disease and metabolic syndrome in Chengdu

OBJECTIVE To investigate and analyze the relationship between non-alcoholic fatty liver disease(NAFLD)and metabolic syndrome(MS).METHODS The disease history were investigated,the general physical data were measured,the biochemical index were detected,upper abdominal ultrasonographic examination were undertaken in 20-80 years old persons in Chengdu who did health examinations in West China Hospital of Sichuan University from February 2011 to May 2011.The data were analyzed by statistical analysis.RESULTS The prevalence rate of NAFLD was 12.33%,and the prevalence of NAFLD and MS was 3.47%.There was an increasing trend in the prevalence of NAFLD and MS with the increase of body mass index(BMI).The BMI,systolic blood pressure,diastolic blood pressure,fasting plasma glucose,triglyceride and low density lipoprotein of the NAFLD group were significantly higher than those of the normal group(P﹤0.01);The high density lipoprotein was lower than that of the normal group(P﹤0.01).The alanine transaminase,aspartate amino transferase and gamma-glutamyl transferase of the NAFLD and MS group were higher than those of the NAFLD group(P﹤0.01).CONCLUSION NAFLD is closely related to the metabolic syndrome.We should pay attention to mutual promotion between NAFLD and MS and give comprehensive prophylaxis and treatment.