三维适形放疗同步TP方案治疗中晚期宫颈癌的临床观察

目的观察三维适形放疗同步TP方案治疗中晚期宫颈癌的的临床疗效。方法将75例中晚期宫颈癌患者随机分为治疗组和对照组,治疗组38例,接受三维适形放疗同步TP(多西紫杉醇+顺铂)方案化疗;对照组37例,接受放疗。结果治疗组的有效率为94.7%,明显高于对照组的70.3%,差异有统计学意义(P﹤0.05)。随访2年,治疗组和对照组的局部复发率分别为7.9%和29.7%,远处转移率分别为10.5%和35.1%,差异均有统计学意义(P﹤0.05)。两组的1、2年生存率分别为92.1%和70.3%,84.2%和62.2%,差异有统计学意义(P﹤0.05)。治疗组的胃肠道副反应、骨髓抑制、放射性直肠炎及放射性膀胱炎的发生率略高于对照组,但差异无统计学意义(P﹥0.05)。结论对于中晚期宫颈癌患者,同步放化疗与单纯放疗相比可降低局部复发率和远处转移率,提高1、2年生存率,是一种安全有效的辅助治疗方法。

Clinical observation of three-dimensional conformal radiotherapy concurrent TP regimen in the treatment of advanced cervical cancer

OBJECTIVE To observe the clinical efficacy of three-dimensional conformal radiotherapy combined with TP regimen in treatment of advanced cervical cancer.METHODS A total of 75 patients with advanced cervical cancer were randomly divided into treatment group and control group.In treatment group,38 patients received simultaneous three-dimensional conformal radiotherapy combined with TP(docetaxel+cisplatin)chemotherapy.In control group,37 patients received radiotherapy.RESULTS The response rate(RR)of treatment group were 94.7%,higher than 70.3% in the control group(P﹤0.05).Up for 2 years,the local recurrence rates in treatment groups and control groups were 7.9% and 29.7%,the distant metastasis rates were 10.5% and 35.1%,there was a significant difference(P﹤0.05).The survival rates at 1,2 year for patients in treatment group vs.control group were 92.1% and 70.3%,84.2% and 62.2%,respectively,there were also a significant difference(P﹤0.05).The incidences of gastrointestinal side effects,bone marrow suppression,radiation proctitis and radiation cystitis in treatment group were slightly higher than control group,but there were no significant differences(P﹥0.05).CONCLUSION For patients with advanced cervical cancer,concurrent chemoradiotherapy can reduce the local recurrence rate and distant metastasis rate,and improve 1,2-year survival rate comparing with radiotherapy alone,and it is a safe and effective adjuvant therapy.