48例静脉药瘾者多重病毒感染临床分析

目的探讨静脉药瘾病毒性肝炎患者多重病毒感染率及转归。方法对48例静脉药瘾病毒性肝炎患者进行乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）、人免疫缺陷病毒（HIV）血清标志物及核酸测定，并进行临床分析。结果48例静脉药瘾病毒性肝炎患者中，HBV、HCV双重感染率为31.25%，HBV、HIV双重感染率为4.17%，HBV、HCV、HIV三重感染率为62.50%；重型肝炎者占70.83%。重型肝炎患者住院时间为（48.67±19.25）d，与同期住院的非药瘾重型肝炎患者住院时间（65.32±31.49）d相比，明显缩短（U=4.25，P＜0.01）。结论静脉药瘾者病毒重叠感染率高，且重型肝炎患者多，但相对非药瘾重型肝炎患者恢复较快。

Clinical analysis on multiple virus infection in 48 cases of intravenous drug addicts

Objective To evaluate the infection rate and prognosis in intravenous drug-addicts. Methods Serological markers and nucleic acid of hepatitis B virus （HBV）, hepatitis C （HCV） and human immunodeficiency virus （HIV） were detected in 48 cases of intravenous drug addicts, and clinical analysis were made. Results Among 48 cases of intravenous drug addicts, double infection of HBV and HCV was 31.25G, double infection of HBV and HIV was 4. 17%, triple infection of HBV, HCV and HIV was 62. 50%; Hepatitis gravis accounted for 70. 83%, the hospitalization time of patients with hepatitis gravis was （48.67 ± 19.25） days, which was obviously shorter than （65. 32 ± 31. 49） days of non-intravenous drug addicts with hepatitis gravis （U = 4. 25, P〈0. 01 ）. Conclusion Superinfection in intravenous drug addicts is high, especially hepatitis gravis, but the prognosis is better than non-intravenous drug addicts.