| 胱抑素C与尿微量白蛋白在2型糖尿病早期肾损害中的临床应用 |
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| 引用本文： | 王伟,马黎丽,王卫国. 胱抑素C与尿微量白蛋白在2型糖尿病早期肾损害中的临床应用[J]. 中国实验诊断学, 2011, 15(10): 1666-1668 |
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| 作者姓名： | 王伟 马黎丽 王卫国 |
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| 作者单位： | 阜阳市人民医院,检验科,安徽,阜阳236004 |
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| 摘 要： | 目的探讨2型糖尿病（T2DM）患者早期肾损害中胱抑素C（CYSC）和尿微量白蛋白（mALB）联合检测的必要性和意义。方法选取118例住院2型糖尿病患者用免疫透射比浊法检测糖化血红蛋白（HBA1c）,按照HBA1c的高低分为控制良好组（A组）和控制不良组（B组）,选取79例健康体检人群作为对照组,用免疫透射比浊法检测CYSC、同时检测尿mALB、Ucr,并进行相关性分析。结果 1.糖尿病组的血清CYSC和尿mALB/Ucr与对照组相比均有显著性差异,且差异具有统计学意义（P〈0.05）;2.随着尿mALB/Ucr的增高血清CYSC显著增高（P〈0.05）,且两者呈正相关。3.在糖尿病组中血清CYSC和尿mALB/Ucr均可能单独升高（P〈0.05）,其中血清CYSC单独升高82例、尿mALB/Ucr单独升高81例,两者联合检测阳性率为76.27%。结论血清CYSC和尿液mALB/Ucr是诊断糖尿病早期肾损害的灵敏指标,临床上结合血清CYSC和尿液mALB/Ucr发现病人早期肾功能改变,能够提高发现糖尿病早期肾损害的敏感性。
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| 关 键 词： | 2型糖尿病 胱抑素C 尿微量白蛋白 |
The clinical application of cystatinc and urine microalbum in type 2 diabetes of early renal damage |
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| WANG Wei,MA Li-li.. The clinical application of cystatinc and urine microalbum in type 2 diabetes of early renal damage[J]. Chinese Journal of Laboratory Diagnosis, 2011, 15(10): 1666-1668 |
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| Authors: | WANG Wei MA Li-li. |
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| Affiliation: | WANG Wei,MA Li-li.(Department of Clinical Laboratory,Anhui fuyang city people's hospital,Fuyang 236004,China) |
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| Abstract: | Objective To explore the necessity and significance combined detection serum CYSC and mALB in in the type 2 diabetic patients(T2DM) with early renal damage.Methods 118 cases of type 2 diabetes in hospital according to the discretion of HBA1c into good control group(group A) and poor control group(group B),79 patients healthy check-up crowd as control group,were determined CYSC HBA1c,urine mALB,Ucr,.Results 1.The CYSC and mALB/ Ucr of diabetic group compared with control group are significant difference(P< 0... |
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| Keywords: | Type 2 diabetes cystatin C urinary albumin |
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