血清C反应蛋白水平与脑梗死预后的关系

目的探讨血清c反应蛋白（CRP）水平与脑梗死患者预后的关系。方法对114例脑梗死患者（脑梗死组）及健康体检者80例（对照组）均采用散射浊度法测定血清CRP水平，参照临床神经功能缺损程度评分标准（NDS）评估脑梗死患者的预后，对血清CRP水平与脑梗死患者预后的关系进行分析。结果脑梗死组血清CRP阳性78例，阳性率为68．42％，对照组血清CRP均阴性。脑梗死组血清CRP水平为（6．51±1．95）mg·-1，对照组血清CRP水平为（1．62±0．87）mg·L-1，脑梗死组血清CRP水平明显高于对照组（P〈0．01）。脑梗死组患者血清CRP水平随NDS评分的下降而增高，脑梗死组各亚组间血清CRP水平比较差异有统计学意义（P〈0．05）。结论血清CRP水平与脑梗死预后关系密切，血清CRP水平越高，病情越重，预后越差；而血清CRP水平越低则其预后越好。CRP可作为监测及评估脑梗死患者预后情况的重要指标：降低血清CRP水平有助于减低脑梗死发生率及改善脑梗死患者的预后。

Relationship between Serum C-reactive Protein Levels and Prognosis in Cerebral Infarction

Objective To investigate the relationship between serum C-reactive protein （CRP） levels and prognosis in cerebral infarction. Methods Serum CRP levels were measured by nephelometry in 114 patients with cerebral infarction and 80 healthy subjects. The prognosis of patients with cerebral infarction was evaluated according to clinic neurological function deficit scale （NDS）. The relationship between CRP levels and prognosis was analyzed. Results Among the 114 patients with cerebral infarction, CRP test was positive in 78 （68.42%）. However, CRP test was negative in all healthy subjects. The concentrations of serum CRP in cerebral infarction patients were significantly higher than those in healthy subjects [ （6.51 ＋ 1.95 ） mg. L-l vs （ 1.62＋0.87 ）mg＂ L-~, P〈0.01 ]. In addition, serum CRP levels in cerebral infarction patients increased with the decline of NDS scores. The differences in serum CRP levels were statistically significant among different cerebral infarction subgroups （P〈0.05）. Conclusion Serum CRP levels were closely related to the prognosis of cerebral infarction. The increased serum CRP levels in patients with cerebral infarction predict severe illness condition and bad prognosis. CRP can be used as an important indicator to monitor and evaluate the prognosis of patients with cerebral infarction. The decrease in serum CRP levels may contribute to the reduction in the incidence of cerebral infarction and the improvement in the prognosis of the patients with cerebral infarction.