细胞因子基因多态性与肝纤维化发展关系的研究进展

慢性肝炎导致肝纤维化进而发展成肝硬化、肝癌等疾病的发生机制复杂，目前尚未全完阐明。细胞因子在肝纤维化发展过程起到了重要的调控作用，研究发现其基因多态性与肝纤维化的发展及药物治疗效果具有密切的联系，为临床预测和诊断以及实现个体化用药提供了依据。本文选取了与肝纤维化关系密切的细胞因子基因多态性与肝纤维化发展关系进行综述，为以后的研究提供参考。

Study progress of relationship between cytokines gene polymorphism and liver fibrosis

The mechanism that chronic hepatitis leads to hepatic fibrosis which can further develop into cirrhosis and liver cancer is complex and has not been fully elucidated. Cytokines play important roles in process of liver fibrosis. A close relation has been found between gene polymorphism of cytokines, hepatic fibrosis and effects of drugs, providing a basis for clinical prediction and diagnosis as well as individualized medication. In order to provide a reference for future research, this article has selected cytokines linked with liver fibrosis and made an review.