| 曲安奈德纳米滴眼液体外转运特性初评 |
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| 引用本文： | 杜有云,班俊峰,张彦,邓广汉,方若槐,曾东敏,陈燕忠,吕竹芬. 曲安奈德纳米滴眼液体外转运特性初评[J]. 中国医院药学杂志, 2016, 36(12): 968-972. DOI: 10.13286/j.cnki.chinhosppharmacyj.2016.12.03 |
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| 作者姓名： | 杜有云 班俊峰 张彦 邓广汉 方若槐 曾东敏 陈燕忠 吕竹芬 |
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| 作者单位： | 1. 广东药学院, 广东 广州 510006;2. 广东省药物新剂型重点实验室, 广东 广州 510006 |
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| 基金项目： | 2015年广东高校省级重点平台和重大科研"青年创新人才"资助项目、广东药学院"创新强校工程"资助项目研究成果(编号:2015KQNCX077);2014年大学生创新训练计划项目(编号:2014035);2015广东省普通高校创新团队建设项目(自然科学)项目(编号:2015KCXTD026) |
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| 摘 要： | 目的:制备以PLGA和2-HP-β-CD为载体的曲安奈德(TA)滴眼液,并对其体系进行表征。方法:采用乳化溶剂挥发法制备TA-PLGA-2-HP-β-CD滴眼液,通过差示扫描、傅立叶红外、X-射线粉末衍射等方法对其理化性质进行表征,并对体外转运特性进行探讨。结果:所制备滴眼液中的纳米粒粒径为(161.7±45.5)nm,ζ-(-6.27±0.12)mV,包封率为(76.39±4.84)%,体外6 h单位面积累积释放度为40%。结论:TA-PLGA-2-HP-β-CD滴眼液体外释放规律符合零级动力学方程,其体外转运特性可为滴眼液的细胞动力学过程的选择和设计提供定量描述的基础。
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| 关 键 词： | 曲安奈德 黄斑性病变 靶向性 纳米给药体系 |
| 收稿时间： | 2015-10-27 |
Preliminary evaluation of in vitro transportation characteristics of triamcinolone acetonide eyedrops |
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| DU You-yun,BAN Jun-feng,ZHANG Yan,DENG Guang-han,FANG Ruo-huai,ZENG Dong-min,CHEN Yan-zhong,LYU Zhu-fen. Preliminary evaluation of in vitro transportation characteristics of triamcinolone acetonide eyedrops[J]. Chinese Journal of Hospital Pharmacy, 2016, 36(12): 968-972. DOI: 10.13286/j.cnki.chinhosppharmacyj.2016.12.03 |
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| Authors: | DU You-yun BAN Jun-feng ZHANG Yan DENG Guang-han FANG Ruo-huai ZENG Dong-min CHEN Yan-zhong LYU Zhu-fen |
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| Affiliation: | 1. Guangdong Pharmaceutical University, Guangdong Guangzhou 510006, China;2. Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Guangzhou 510006, China |
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| Abstract: | OBJECTIVE To characterize and evaluate in vitro transportation characteristics of triamcinolone acetonide eyedrops with PLGA and 2-HP-β-CD as carriers.METHODS TA-PLGA-2-HP-β-CD eyedrops were prepared by modified emulsion solvent evaporation method. Then in vitro evaluations were conducted by tests of entrapment efficiency, accumulative release, morphous investigation, DSC, FT-IR and X-ray powder.RESULTS Mean entrapment efficiency of triamcinolone acetonide loaded nanocarriers was (76.39±4.84)%. Average size was (161.7±45.5)nm and in vitro cumulative release of triamcinolone acetonide from nanocarriers was 40% in 6 h.CONCLUSION Release in vitro of TA-PLGA-2-HP-β-CD eyedrops is accordant with zero order model. Intracellular kinetics can provide some information on rational choices and design of nanoparticles drug delivery system. |
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| Keywords: | triamcinolone acetonide macular degeneration target nanotechnology |
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