自发性高血压大鼠行为学的初步观察

背景注意缺陷多动障碍(attention deficit hyperactivity disorder, ADHD)存在着强化机制的异常,而多动性是强化机制异常的一种表现.目的观察 ADHD动物模型自发高血压大鼠( SHR)的多动性变化,以探究其强化机制.设计非随机对照的实验研究.地点、材料和干预实验在挪威奥斯陆大学医学系生理实验室进行.实验选用12只雄性 SHR大鼠和 12只雄性 Wistar Kyoto( WKY)大鼠.实验在标准 Campden连续反应测试箱中进行,大鼠禁水22 h,采用长变异间期方案(变异指数 180 s),分析最后 10 d稳定曲线的均值.主要观察指标大鼠按杠次数、推门次数及在不同阶段的变化.结果① SHR组大鼠按杠次数 [(642.9± 173.1)次 ]显著多于 WKY组 [(219.9± 79.5)次〗(t=7.52, P《 0.01).②实验过程的 3个相同阶段 SHR大鼠的按杠次数比较,差异无显著性意义(F=0.10, P 》0.05).③ SHR组的推门次数明显多于 WKY组 (t=4.43, P《 0.01),而获水次数与WKY组比较,差异无显著性意义 (t=1.86, P 》0.05).结论 SHR大鼠的多动性较WKY大鼠强,强化机制异常,有助于了解 ADHD的发病机制、临床治疗及预防.

Elementary behavioralobservation of spontaneous hypertensive rat

BACKGROUND:Attention deficit hyperactivity disorder(ADHD) has abnormal strengthening mechanism and hyperactivity is one of the expressions of this abnormal strengthening mechanism. OBJECTIVE:To investigate the behavioral variations of spontaneous hypertensive rat(SHR),an ADHD animal model,for the exploration of its strengthening mechanism. DESIGN:A non-randomized controlled trial. SETTING,PARTICIPANTS and INTERVENTIONS:The study was conducted in the Laboratory of Physiology of the Faculty of Medicine of the University of Oslo,Norway.12 male SHR rats and 12 male Wistar Kyoto(WKY) rats were selected.The experiment was carried on in the standard Campden instrument operant chambers.The animals were water deprived for 22 hours.A long Variable Interval Schedule(variable index:180 s) was used to analyze the mean value of the stable curve of the last ten days. MAIN OUTCOME MEASURES:The times of lever-pressing and door-opening and the variation at different stages. CONCLUSION:The hyperactivity of SHR is much more obvious than that of the WKY and it has abnormal strengthening mechanism,which is helpful for the investigation of the pathogenesis and clinical therapy and prevention of ADHD.