| 腺苷与AMP579对冠心病患者CD62P表达的影响 |
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| 引用本文： | 菅寅生,王雄. 腺苷与AMP579对冠心病患者CD62P表达的影响[J]. 中西医结合心脑血管病杂志, 2010, 8(4): 406-408 |
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| 作者姓名： | 菅寅生 王雄 |
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| 作者单位： | 山西医科大学第一医院,030001 |
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| 基金项目： | 山西省归国留学基金资助项目 |
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| 摘 要： | 目的 探讨不同剂量腺苷与AMP579对冠心病(CHD )患者血小板表面CD62P表达的影响.方法 选择经临床症状、心电图改变及心肌酶学确诊的CHD患者30例及正常健康者15名,采集肘静脉血,分别给予不同剂量的腺苷与AMP579,用双抗体夹心酶联免疫吸附法( ELISA)检测患者及正常人用药前后血小板CD62P表达值.结果 CHD患者的血小板CD62P的表达升高,与正常人比较差异有统计学意义(P<0.05);腺苷和AMP579均能降低CHD患者血小板CD62P的表达,分别与用药前比较差异有统计学意义(P<0.05),但同一药物在450 μmol/L、1 000 μmol/L、3 000 μmol/L 3种浓度下对CD62P表达的影响无统计学意义(P>0.05).结论 CHD的发生可能与CD62P表达升高有关;腺苷和AMP579可通过降低CD62P表达而降低血小板与内皮下基质的黏附,从而起到防止血栓的作用.
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| 关 键 词： | 冠心病 血小板 腺苷 |
The Influence of Adenosine and AMP579 on Expression of Platelet CD62P in Patients with Coronary Heart Disease |
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| Jian Yinsheng,Wang Xiong The First Hospital,Shanxi Medical University. The Influence of Adenosine and AMP579 on Expression of Platelet CD62P in Patients with Coronary Heart Disease[J]. Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease, 2010, 8(4): 406-408 |
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| Authors: | Jian Yinsheng Wang Xiong The First Hospital Shanxi Medical University |
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| Affiliation: | Jian Yinsheng,Wang Xiong The First Hospital,Shanxi Medical University(Taiyuan 030001) |
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| Abstract: | Objective To explore the influence of different doses adenosine and AMP579 on the expression of adhesion molecules CD62P of platelet in patients(pts) with coronary heart disease(CHD).Methods The cubital vein blood of the CHD pts(n=30) and normal healthy subjects(n=15) were collected,and different doses of adenosine and AMP579 were given.The expression of platelet CD62P were measured by enzyme-linked immunosorbent assays.Results Expression of platelet CD62P in pts with CHD were markedly higher than that in s... |
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| Keywords: | CD62P AMP579 |
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