| 苯接触与尿中反-反式黏糠酸和苯巯基尿酸关系研究 |
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| 引用本文： | 相红,宋世震,陈斯琦,梅勇,叶方立. 苯接触与尿中反-反式黏糠酸和苯巯基尿酸关系研究[J]. 工业卫生与职业病, 2010, 36(1): 19-22 |
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| 作者姓名： | 相红 宋世震 陈斯琦 梅勇 叶方立 |
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| 作者单位： | 武汉科技大学医学院,湖北,武汉,430065;武汉科技大学医学院,湖北,武汉,430065;武汉科技大学医学院,湖北,武汉,430065;武汉科技大学医学院,湖北,武汉,430065;武汉科技大学医学院,湖北,武汉,430065 |
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| 摘 要： | 目的探讨职业苯接触与尿中反-反式黏糠酸(ttMA)和苯巯基尿酸(SPMA)的相关性,评定两接触标志物作为生物监测指标的适用性。方法对44名制鞋厂接苯工人进行个体苯暴露水平的作业环境监测,采集当日班前与班后尿样,分别用高效液相色谱和液质联谱测定尿中ttMA和SPMA含量。结果个体苯接触浓度为2.57~146.11 mg/m3,几何平均浓度为(27.91±3.29)mg/m3。班后尿中ttMA和SPMA含量均较班前增高,差异有统计学意义(P0.01),班后ttMA和SPMA与空气苯浓度的相关系数分别为0.905(P0.01)和0.537(P0.01),个体苯接触代谢转化为ttMA和SPMA的相对内暴露指数(RIE)随苯接触浓度的增高而下降。结论在中、高浓度的苯接触时,班后尿ttMA与空气苯浓度的相关性优于SPMA。
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| 关 键 词： | 苯 生物监测 反-反式黏糠酸 苯巯基尿酸 |
Benzene Exposure and Its Relationship to Urinary Metabolites Trans,trans-muconic Acid and S-phenylmercapturic Acid |
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| XIANG Hong,SONG Shi-zhen,CHEN Si-qi,MEI Yong,YE Fang-li. Benzene Exposure and Its Relationship to Urinary Metabolites Trans,trans-muconic Acid and S-phenylmercapturic Acid[J]. Industrial Health and Occupational Diseases, 2010, 36(1): 19-22 |
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| Authors: | XIANG Hong SONG Shi-zhen CHEN Si-qi MEI Yong YE Fang-li |
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| Affiliation: | Medical College;Wuhan University of Science & Technology;Wuhan 430065 China |
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| Abstract: | Objective To investigate correlation of occupational benzene exposure with urinary trans,trans-muconic acid(ttMA) and S-phenylmercapturic acid(SPMA),and assess the applicability of biomarkers in bio-monitoring of benzene exposure.Methods Benzene exposure was measured in 44 shoe-makers and air samples were collected with personal samplers.Pre-shift and post-shift urine samples were collected for ttMA determination by HPLC and for SPMA measurement by HPLC-MS.Results The personal benzene exposure ranged from 2... |
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| Keywords: | Benzene Biological monitoring Trans Trans-muconic acid S-phenylmercapturic acid |
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