感染性休克时内环境紊乱与治疗策略

感染性休克可引起机体代谢、凝血、内分泌等系统功能障碍,从而导致一系列内环境紊乱。正确认识这些内环境紊乱及对机体的不利影响,采取恰当的治疗策略是非常重要的。关于感染性休克时代谢性酸中毒的纠正、凝血障碍及应激性高血糖的治疗目前尚有争议,应遵循根据循证医学证据制订的指南推荐意见。

Dysregulation of homeostasis and therapeutic option in septic shock

Septic shock may have a lasting effect on all human endocrinologic,coagulatory and metabolic regulatory circuits with the consequence of severe dysregulation of homoeostasis. Adjunctive therapeutic options like correction of metabolic acidosis,intensive insulin therapy,and modulation of coagulation by drotrecogin alfa (activated) are still controversial. However,these adjunctive therapeutic options should be selected according to the national and international guidelines.