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| nm23/NDPK在胃癌的表达及临床意义 | |
| 引用本文： | 任鸿. nm23/NDPK在胃癌的表达及临床意义[J]. 山西职工医学院学报, 2003, 13(2): 1-3 |
| 作者姓名： | 任鸿 |
| 作者单位： | 山西省沁源县人民医院,山西,沁源,046500 |
| 摘 要： | 目的：探讨肿瘤转移抑制相关基因表达水平与胃癌生物学行为的关系。方法：采用免疫组织化学LSAB法分析nm23／NDPK在胃癌的表达及其与多种指标的关系。结果：nm3／NDPK表达强度随肿瘤临床分期和病理分级的增高而增高。高分化肿瘤nm3／NDPK的表达明显低于中、低分化肿瘤，有淋巴结转移者nm63／NDPK的表达显著低于未转移者。结论：nm3／NDPK可能在胃癌的发生及转移中起不同的调节作用，可作为评价胃癌恶性程度、肿瘤进展及预后的指标。 |
| 关 键 词： | nm23／NDFK 胃癌 基因表达 临床意义 免疫组织化学 |
| 文章编号： | 1671-0126(2003)02-0001-03 |
| 修稿时间： | 2003-01-10 |
The Expression of nm23 Genes in Gastric Carcinoma |
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| REN Hong. The Expression of nm23 Genes in Gastric Carcinoma[J]. Journal of Shanxi Medical College For Continuing Education, 2003, 13(2): 1-3 | |
| Authors: | REN Hong |
| Abstract: | Objective: The expression of nm23 genes/NDPK was studied in order to evaluate its clinical significance.Methods: The expression of nm23/NDPK genes was examined and several parameters of gastric carcinoma were analyzed.Results: The expressive intensity of nm23 genes/NDPK was associated with the stages and the grading of the tumor.Positive rates in the well differentiated gastric carcinoma were lower than those of moderately and poorly differentiated.Expression rate in patients with lymphatic metastasis was lower.Conclusion: nm23/NDPK might exert varied modulating actions on the genesis and metastasis of gastric carcinoma.Therefore,it may serve as a parameter to judge malignancy,progression and prognosis. |
| Keywords: | gastric carcinoma gene neoplasm immunhistochemistry |
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