Interactions between septal and entorhinal inputs to the rat dentate gyrus: Facilitation effects |
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| Authors: | G.B. Robinson R.J. Racine |
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| Affiliation: | 1. Physiological Chemistry Department, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA;2. WEHI: Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia;3. Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3010, Australia;1. Membrane Technology Department, Institute of Functional Interfaces (IFG), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany;2. School of Engineering and Electronics, The University of Edinburgh, Edinburgh EH9 3JL, United Kingdom;1. College of Chemical Engineering, Jiangsu Key Lab for the Chemistry & Utilization of Agricultural and Forest Biomass, Nanjing Forestry University, Nanjing, Jiangsu 210037, China;2. College of Chemical Engineering, Tianjin University, Tianjin 300073, China;1. School of Materials and physics, China University of Mining & Technology, Xuzhou 221116, PR China;2. Jiangsu Province Engineering Laboratory of High Efficient Energy Storage Technology and Equipments, China University of Mining & Technology, Xuzhou, PR China |
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| Abstract: | We examined facilitation effects between the medial septum and perforant path inputs to the dentate gyrus for the four possible combinations of paired-pulse activation. Facilitation effects occurred in all cases. The largest facilitation effects occurred when the septal pulse served as the conditioning pulse for the population spike subsequently evoked by a perforant path pulse. Using 3 pulses, we also examined the influence of septal activation on paired-pulse facilitation of the perforant path-granule cell population spike. A septal stimulation pulse, applied 6-10 ms prior to the onset of the population spike evoked by a perforant path conditioning pulse, did not affect the perforant path-dentate test response at any interpulse interval. If the septal pulse occurred immediately prior to population spike onset, however, there was a significantly greater depression of the test response from 70-3000 ms, but no effect at early intervals (20-50 ms). The effect of the septal pulse appears more consistent with a direct action of the septal terminals on granule cells than with an indirect action via the recurrent inhibitory interneurons. |
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| Keywords: | facilitation depression paired-pulse entorhinal cortex septum dentate gyrus |
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