Characterization of the tumour necrosis factor receptor in human placenta |
| |
| Authors: | D K Eades P Cornelius P H Pekala |
| |
| Affiliation: | Department of Biochemistry, School of Medicine, East Carolina University, Greenville, NC 27858. |
| |
| Abstract: | ![]()
A specific receptor for tumour necrosis factor present in a purified plasma membrane preparation from the villous tissue of human placenta has been characterized. The data fit a one-class-of-sites model exhibiting a KD = 28.4 (+/- 0.002) nM, with 8.1 (+/- 0.05) X 10(11) receptors mg-1 membrane protein. These data provide evidence for the existence of a specific receptor for a major endotoxin-induced cytokine in the placenta. |
| |
| Keywords: | |
|
|
