利维爱对绝经后妇女骨密度及骨代谢指标的影响

目的了解利维爱对绝经后妇女骨密度及骨代谢指标的影响 . 方法将 123例自然绝经后妇女随机分 2组 研究组每日口服利维爱 1.25 mg+ 钙尔奇 D 600 mg, 对照组每日口服钙尔奇 D 600 mg, 观察 12个月 . 用药前后分别检测腰椎 (L 2～ 4)及股骨颈 (NK)骨密度 (BMD)骨代谢指标血清骨钙素 (BGP)和碱性磷酸酶 (AKP)及尿吡啶酚 /肌酐 (Pyr/cr)和钙 /肌酐 (Ca/Cr)比值 . 结果 (1)L 2～ 4、 NK两部位 BMD 研究组治疗后均增加 , 且前者上升有显著性差异 (P< 0.05);对照组均下降无显著性差异 (P >0.05);治疗后 2组间比较有显著性差异 (P< 0.01,P< 0.05). (2)生化指标血 BGP、 AKP及尿 Pyr/Cr、 Ca/Cr 治疗后研究组均上升有显著性差异 (P< 0.01,P< 0.05); 对照组变化无显著性差异 (P >0.05). 结论绝经后妇女每日服用 1.25 mg利维爱加钙尔奇 D可以提高骨量 ; 单用钙尔奇 D不能防止骨丢失 .

The effects of tibolone on bone mineral density and biochemical bone markers in older women

Objective The effects of tibolone on bone mineral density and biochemical bone markers in older women were assessed.Method 123 cases of late postmenopausal women were randomly divided into 2 groups.63 patients of the observed group were given tibolone 1.25 mg/d plus calcium carbonate vitamin D 600 mg/d.60 patients of the control group took calcium carbonate vitamin D 600 mg/d.The main outcome measures were bone mineral density(BMD)and biochemical markers of bone resorption and formation at baseline and 12 moths on treatment.Result BMD from the fourth lumbar vertebra and neck in the observed group incresaed respectivly.At the same,serum levels of osteocalin,alkaline and urinary pyidinoline/creatinine and calcium/creatinine ration all decreased significantly.The control group did not have remarkable changes after treatment.Conclusion Small dosage of tibolone (1.25 mg/d)may increase bone mass and reduce bone turnover in older women.Using calcium carbonate vitamin D alone could not prevent bone loss in older women.