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A pediatric intramedullary spinal cord tumor with unusual solid‐cystic and papillary features: A case report
Authors:Takeshi Iwasaki  Masako Kato  Yasushi Horie  Shinsuke Kato  Keiichi Akatsuka  Takashi Watanabe  Satoshi Kuwamoto  Ichiro Murakami  Kazuhiko Hayashi
Affiliation:1. Division of Molecular Pathology, Department of Microbiology and Pathology;2. Division of Pathology, Tottori University Hospital, Yonago, Japan;3. Division of Neuropathology;4. Division of Neurosurgery, Department of Brain and Neurosciences, Tottori University Faculty of Medicine
Abstract:
Spinal cord tumors are rare in children. We report a novel case of pediatric intramedullary spinal cord tumor with unusual solid‐cystic and papillary features. Clinically, the patient presented at the age of 3 years with motor deficit and urinary incontinence, and MRI demonstrated multilocular cystic lesions in the thoracic spine. Histologically the tumor consisted of solid, sheet‐like components and branching papillary structures, and immunohistochemistry demonstrated positive reactivity for epithelial membrane antigen, cytokeratins (7, AE1/3, CAM5.2), E‐cadherin and transthyretin, and negativity for GFAP, S‐100 protein, synaptophysin and neurofilament. These histological and immunohistochemical findings appeared to be unique, and were not compatible with the features of classical ependymoma or choroid plexus papilloma. The clinical behavior, characterized by relatively rapid tumor regrowth after surgical resection and a relatively high MIB‐1 labeling index, suggest that this tumor might have had moderate malignant potential. This pediatric case appears to be particularly informative with regard to the tumor biology or tumorigenesis of intramedullary spinal cord tumor with unusual solid‐cystic and papillary features.
Keywords:children  choroid plexus papilloma  ependymoma  solid‐cystic and papillary  spinal cord neoplasm
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