Synthesis and anti-tuberculous activity of diesters based on isosteviol and dicarboxylic acids |
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| Authors: | V. E. Kataev O. I. Militsina I. Yu. Strobykina G. I. Kovylyaeva R. Z. Musin O. V. Fedorova G. L. Rusinov M. N. Zueva G. G. Mordovskoi A. G. Tolstikov |
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| Affiliation: | (1) Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Kazan, Tatarstan, 420088, Russia;(2) Institute of Organic Synthesis, Ural Division of the Russian Academy of Sciences, Yekaterinburg, 620219, Russia;(3) Phthisiopulmonology Research Institute, Ministry of Public Health of the Russian Federation, Yekaterinburg, Russia;(4) Institute of Technical Chemistry, Ural Division, Russian Academy of Sciences, Perm, Russia |
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| Abstract: | Diesters based on isosteviol and dicarboxylic acids were synthesized and tested for antituberculous activity. Isosteviol and some of its derivatives exhibit appreciable tuberculostatic properties in vitro, the activity being dependent on the length of the polymethylene spacer connecting two ent-beyeran fragments. The mechanism of the antituberculous action of isosteviol derivatives are discussed. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 9, pp. 12–13, September, 2006. |
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