颈动脉斑块形成危险因素的多因素Logistic回归分析

目的了解颈动脉斑块形成的危险因素，为更好地防治颈动脉斑块形成提供依据。方法收集2008年7月至2014年2月在北海市第二人民医院住院治疗的723例患者，其中492例伴有颈动脉斑块（斑块组），231例无颈动脉斑块（无斑块组）。所有病例均常规检测总胆固醇（TC）、低密度胆固醇（LDL）、甘油三酯（TG）和高密度胆固醇（HDL），并用彩超检查颈动脉斑块，将性别、年龄、高血压、糖尿病、TC、LDL、TG和HDL多个颈动脉斑块形成的危险因素进行Logistic回归分析。结果斑块组平均年龄（72．20±11．12）岁，高于无斑块组，差异有统计学意义（t=9．909，P〈0．01）；且血清TC、TG和LDL分别为（5．38±1．41）、（1．63±0．91）和（3．56±1．18）mmol／L，也均高于无斑块组，差异均有统计学意义（t=5．255、2．785、5．261，P均〈O．01），而两组HDL比较，差异无统计学意义（t=-1．096，P〉0．05）。Logistic回归分析显示，男性（OR=I．571，95％CI：1．116±2．212）、年龄≥65岁（0尺=3．116，95％CI：2．201～4．410）、高血压（0R=1．699，95％Ch1．184-2．438）、LDL≥3．3mmol／L（DR=1．779，95％Ch1．161～2．726）和TG≥1．8mmol/L（0R=1．575，95％CI：1．064～2．333）5种因素可能与颈动脉斑块的形成相关。结论男性、年龄≥65岁、高血压、LDL≥3．3mmol／L和TG≥1．8mmol／L为颈动脉斑块形成的危险因素。

Risk factors of atherosclerotic plaque in the carotid： a multivariate Logistic

Objective To investigate the risk factors of atherosclerotic plaque in the carotid, in an attempt to find better measures for prevention and treatment of the disease. Methods A total of 723 patients admitted in the Second People＇s Hospital of Beihai from July 2008 to February 2014 were enrolled and were divided into carotid plaque group （n=492） and non-carotid-plaque group （n=231）. The contents of otal cholesterol （TC）, low density lipoprotein cholesterol （LDL）, triglyceride （TG） and high density lipoprote cholesterolin （HDL） in all patients were detected, and color doppler ultrasound was used to detect carotid plaque. Risk factors were analyzed by logistic regression. Results The mean age was （72.20± 11.12） years in carotid plaque group, older than that in non-carotid-plaque group with a significant difference （t =9.909, P〈0.01 ）. Compared with non-carotid-plaque group, the levels of TC （5.38±1.41 mmol/L）, TG （1.63±0.91 mmol/L）and LDL-C （3.56±1.18 retool/L） were significantly higher in carotid plaque group （t=5.255,2.785,5.261, all P〈0.01）; the level of HDL did not differ between two groups （t =- 1.096, P〉0.05 ）. Logistic regression analysis showed that male （OR = 1.571, 95% CI： 1.116- 2.212）, older than 65 years （OR=3.116, 95%CI： 2.201-4.410）, hypertension （OR=1.699, 95%CI： 1.184-2.438）, LDL≥3.3 mmol/L （OR=1.779, 95%CI： 1.1611-2.726）, and TG≥1.8 mmol/L （OR=1.575, 95%CI： 1.064-2.333） were risk factors associated with the prevalence of atherosclerotic plaque in the carotid. Conclusions Male, older than 65 years, hypertension, LDL≥3.3 mmol/L, and TG ≥1.8 mmol/L are risk factors of carotid atherosclerotic plaque.