松果腺切除对长期游泳老龄小鼠MDA影响的对比研究

为研究长期游泳运动老龄小鼠脂质过氧化水平的降低是否与刺激了松果腺释放褪黑素有关,将松果腺切除12月龄昆明种小鼠分为手术组(n=36)、非手术组(n=36)和假手术组(n=12),前2组又各分为对照组、60min组和60min+3%体质量负荷组,对其血清中的MDA浓度进行对比研究.结果:雄性小鼠非手术组中MDA浓度60min组及60min+3%负荷组均显着低于手术同负荷组(P<0.05,P<0.01).雌性小鼠,非手术组60min组MDA浓度显着低于手术组(P<0.05).而在60min+3%负荷组,手术组要显着低于非手术组(P<0.05).提示:长期运动训练降低血清脂质过氧化水平,可能与交感神经兴奋性升高刺激松果腺内褪黑素的合成和释放有关;如果选择负荷不当,会对松果腺机能产生抑制,而对机体抗氧化能力的提高产生负面影响.

Effect of Pinealectomy on Serum MDA Level in Old Swimming Mice

The objective was to investigate if melatonin is related with the decrease of MDA by pinealectomy mice during long term aerobic exercise. Pinealectomied 12-month-old mice were divided into three groups: the control, the swimming-60-min and the 60-min with 3% body mass; and normal mice also were divided three groups in the same way. After eight weeks swimming, all animals were killed, and their MDA levels in serum were assayed. Results: In male mice MDA decreased significantly in normal mice than in the pinealectomied in the swimming-60-min and the swimming-60-min with 3% body mass. while in female mice, the swimming-60-min group has shown the same results as above, but in the swimming-60-min with 3% body weight group the level MDA in pinealectomied group decreased significantly than in the normal group. Conclusion: long term suitable intensity aerobic exercise can enhance the activity of antioxidase, and it is related with stimulating pineal and releasing melatonin.