缬沙坦对兔急性心肌梗死血小板活化、纤溶活性和内皮血管活性物质的影响

目的　探讨缬沙坦对急性心肌梗死血小板活化、纤溶活性和内皮血管活性物质的影响。方法　新西兰大白兔30只 ,随机分为三组 ,每组 10只 , 组 :假手术组 , 组 :急性心肌梗死组 , 组 :缬沙坦组 ; 、 组分别结扎冠状动脉左室支中点后 4 h,取血分别测定血栓素 B2 (throm boxane B2 ,TXB2 )、6 -酮 -前列腺素 F1α(6 - Keto- prostaglandinF1α,6 - Keto- PGF1α)、内皮素 (Endothelin,ET)、一氧化氮 (Nitric oxide,NO)浓度以及组织型纤溶酶原激活剂 (tis-sue- type plasminogen activator,t- PA)和纤溶酶原激活剂抑制物 (Plasm inogen activator inhibitor,PAI)活性 ;摘取心脏 ,测定心肌梗死范围。结果　 、 组与 组比较 ,血浆 TXB2 、ET、NO浓度和 PAI活性显著升高 (P<0 .0 1) ,6 - Keto- PGF1α浓度、t- PA活性显著下降 (P<0 .0 1) , 组与 组比较 ,血浆 TXB2 、ET、NO浓度和 PAI活性明显降低 (P<0 .0 1) ,6 - Keto- PGF1α浓度、t- PA活性显著升高 (P<0 .0 1) ,梗死范围减小。结论　缬沙坦抑制急性心肌梗死早期血小板活化 ,改善纤溶活性 ,减少 ET和 NO的释放 ,缩小心肌梗死范围

Effects of valsartan on platelet activation, fibrinolytic activity and vasoactive mediators in rabbits with acute myocardial infarction

Objective To explore the effects of valsartan on platelet activation, fibrinolytic activity and vasoactive mediators in rabbits with acute myocardial infarction Methods Thirty New Zealand white rabbits were randomly divided to three groups,ten for each. Group Ⅰ: Sham group, Group Ⅱ: Acute myocardial infarction group, Group Ⅲ: Valsartan group.The middle point of left ventricular coronary artery was ligated(GroupⅡ,Ⅲ ) or a sham ligation(Group Ⅰ), four hours later, blood was collected for measuring plasma concentration of thromboxane B 2 (TXB 2), 6 Keto prostaglandin F 1α (6 Keto PGF 1α ) , Endothine(ET) and Nitric oxide(NO),as well as plasma activity of tissue type plasminogen activator (t Pa) and Plasminogen activator inhibitor(PAI ).After that, the heart was taken out to evaluate the infarct size(IS). Results Plasma concentration of TXB 2, ET and NO and plasma activity of PAI were significantly higher in Group Ⅱand Ⅲ than those in Group Ⅰ( P <0.01),but the plasma concentration of 6 Keto PGF 1α and plasma activity of t Pa were remarkably decreased in Group Ⅱand Ⅲ than those in Group Ⅰ( P <0.01). Comparing Group Ⅱ, Plasma concentration of TXB 2, ET and NO and plasma activity of PAI were significantly decrease( P <0.01),conversely, the plasma concentration of 6 Keto PGF 1α and plasma activity of t Pa were remarkably increase( P <0.01), the infarct size were significantly decrease( P <0.01)in Group Ⅲ. Conclusion Valsartan can inhibit platelet activation, improve fibrinolytic activity, decrease release of ET and NO in AMI and decrease infarct size.