心踝血管指数与高血压血管病变的相关性研究

目的 探讨高血压患者心踝血管指数（CAVI）及其相关因素分析.方法 入选体检男性375人,分为对照组（n=233）和高血压组（n=142）.应用动脉僵硬度自动检测装置测定CAVI,作为反映动脉僵硬度的指标.分别应用腹主动脉CTA、直接眼底镜检测腹主动脉及眼底动脉硬化情况.结果 高血压患者CAVI水平显著高于对照组（8.15±1.15 vs.7.66±1.00,P＜ 0.001）.腹主动脉硬化、眼底动脉硬化组CAVI水平显著高于对照组（8.59±0.52 vs.7.74±0.98,P＜0.001;8.38±0.86 vs.7.60±0.95,P＜0.001）.总体人群中,CAVI与年龄、颈-股动脉脉搏波传导速度（cfPWV）、收缩压（SBP）、舒张压（DBP）、脉压（PP）、甘油三酯（TG）、糖化血红蛋白（HbA1c）分别呈显著相关性（r=0.578、0.480、0.236、0.115、0.249、0.131、0.226,P均＜0.05）.多元回归分析提示年龄、HbA1c是CAVI的独立影响因素（β=0.508,P＜ 0.001;β=0.189,P=0.010）.结论 高血压患者CAVI水平明显升高,CAVI是高血压患者大血管、微血管病变的良好评价指标.

Possible association between cardio-ankle vascular index and vascular lesion in hypertension subjects

Objective To investigate the possible risk factors involving cardio-ankle vascular index （CAVI） in hypertension subjects. Methods Three hundred and seventy-five male subjects from Shougang Corporation examination center were enrolled into our study. They were divided into two groups： the normal group （n=233）, the hypertension group （n=142）. The VS-1000 was used to measure CAVI. Carotid-femoral pulse wave velocity （cfPWV） was detected by the Complior apparatus. Status of abdominal aortic arteriosclerosis was detected by CT angiography. Retinal artery arteriosclerosis was detected by direct ophthalmoscope. Results The value of CAVI was higher in hypertension subjects than that of healthy group （8.15±1.15 vs. 7.66±1.00, P 〈 0.001）. The level of CAVI was increased in subjects with abdominal aortic or retinal artery arteriosclerosis than that of normal arteries （8.59±_0.52 vs. 7.74±0.98, P 〈 0,001 ;8.38±0.86 vs. 7.60±0.95, P 〈 0.001）. CAVI was positively correlated with age, cfPWV, SBP, DBP, PP, TG, HbAlc in the entire study group （r = 0.578, 0.480, 0.236, 0.115, 0.249, 0.131, 0.226, respectively, P 〈 0.05）. Multivariate analysis showed that age, HbAlc were independent related factors of CAVI in all subjects （13 = 0.508, P 〈 0.001; J3 = 0.189, P = 0.010）. Conclusion CAVI is high in hypertension subjects, and it is a reliable indicator for arterial stiffness of macro- and micro-vascular complications.