血管紧张素1-7:肾素-血管紧张素系统新调节因子 |
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引用本文: | 卜乐,刘志民. 血管紧张素1-7:肾素-血管紧张素系统新调节因子[J]. 国外医学:内科学分册, 2009, 36(8): 480-483,494 |
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作者姓名: | 卜乐 刘志民 |
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作者单位: | 第二军医大学第二附属医院内分泌科,上海200003 |
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基金项目: | 国家重点基础研究发展计划(973)资助项目 |
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摘 要: | 血管紧张素(Ang)1-7是肾素-血管紧张素系统的新调节因子,它能够拮抗AngⅡ的扩血管和促增殖等效应,并对肾脏发挥复杂的调节作用。通过药物作用干预血管紧张素酶2-Ang-(1-7)-Mas轴的功能,将会为心血管疾病、肾脏、肝脏疾病和糖尿病的治疗提供新的可能。
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关 键 词: | 血管紧张素1-7 Mas受体 血管紧张素酶2 肾素-血管紧张素系统 |
Angiotensin(1-7): a novel renin angiotensin system mediator |
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Affiliation: | BU Le, LIU Zhi-min. (Department of Endocrinology, the Second Affiliated Hospital, the Second Military Medical University, Shanghai 200003, China) |
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Abstract: | As a novel renin angiotensin system mediator Angiotensin( 1-7 ) antagonizes vasodilation and proliferative effects of angiotensin Ⅱ and exerts complex renal actions. We also speculated the possibility of new drugs for the treatment of angiocardiopathy, nephropathy, hepatopathy and diabetic mellitus by interfering with ACE2 -angiotensin- ( 1-7 ) -Mas axis. |
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Keywords: | Angiotensin ( 1-7 ) Mas receptor Angiotensin-converting enzyme 2 Renin angiotensin system |
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