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Changes of the content and distribution of cochlear actin in iron-deficient growing rats
Authors:YUANJun  SUNAi-hua  WANGJin-ling  FANRong  JIAOXi-ying  LINShun-zhang
Affiliation:YUANJun,SUNAi-hua,WANGJin-ling,FANRong,JIAOXi-ying,LINShun-zhang Department of Otolaryngology,Changzheng Hospital,Second Military Medical University,Shanghai200003,Chi na 2 Department of Otolaryngology,Xijing Hospital,Forth Military Medical Uni
Abstract:
Objective:To observethe changesof thecontentanddistributionof cochlearactiningrowingratsatdif-ferentperiodsof irondeficiency (ID)and to explorethepathogeneticmechanismof ID-inducedsensorineuralhear-ingloss.Methods:Actinof cochlearmembranoustissuewasseparatedanddeterminedwithSDS-PAGEandWest-ernblot.Therelativecontentanddistributionof cochlearactinin bothID andnormalratsin week8and12were studiedby TLC-densitometricdeterminationandimmunohistochemicalprocedures.Results:A markedreductionof relativecontentandimmunohistochemicalreactionproductof cochlearactinwasfoundinIDratswithsensorineural hearinglossincomparisonwithnormalcontrols.Therewasno significantdifferenceof cochleaactinamongdiffer-entgroupsof IDratswithhearingloss.Conclusion: ID-inducedsensorineuralhearinglossis probablyassociated withreductionof actininthecochlea.It is suggestedthattheexperimentalID periodof timehaveno considerable effecton therelativecontentanddistributionof cochlearactin.
Keywords:irondeficiency  hearingloss  cochlea  actin
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