Changes and clinical significance of plasma levels of carbon monoxide and nitric oxide in perinatal asphyxial neonates |
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| Authors: | SHI Yuan PAN Feng LI Hua-qiang PAN Jie QIN Shi-wen SHEN Ji-gao |
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| Affiliation: | Department of Pediatrics, Daping Hospital, Third Military Medical University, Chongqing 400042, China Department of Pediatrics, Daping Hospital, Third Military Medical University, Chongqing 400042, China Department of Pediatrics, Daping Hospital, Third Military Medical University, Chongqing 400042, China Department of Pediatrics, Daping Hospital, Third Military Medical University, Chongqing 400042, China Department of Pediatrics, Daping Hospital, Third Military Medical University, Chongqing 400042, China Department of Pediatrics, Daping Hospital, Third Military Medical University, Chongqing 400042, China |
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| Abstract: | Objective:To studythechangesof plasmalevelsof carbonmonoxide(CO)andnitricoxide(NO)in asphyxial neonates.Methods:PlasmaCO andNO levelsof33perinatalasphyxialneonatesand30healthynewborninfantswere measured.Results:TheplasmaCOandNOlevelswerecloselycorrelatedto theoccurrenceandclinicalseverityof hypoxic-ischemicencephalopathy(HIE).TheperinatalasphyxialpatientswithHIEhadsignificantlyhigherCO andNO levelsthan thosewithoutHIEandthenormalcontrols(P<0.05,respectively),andtherewas no significantdifferenceof CO andNO levelsbetweentheperinatalasphyxialnewborninfantswithoutHIEandthenormalcontrols(P>0.05).Moreover,inthe caseswithHIE,theCO andNO levelswerecorrelatedto theseverityof clinicalmanifestations,thatis,thehighertheCO andNOlevels,themoreseveretheclinicalmanifestationsare(P<0.05).Conclusion:Inadditionto NO,CO is anotheren-dogenousmediatorwhichplaysan importantroleintheoccurrenceof HIEinperinatalasphyxialneonates. |
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| Keywords: | asphyxia neonatorum carbon monoxide nitric oxide |
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