血清肿瘤异常蛋白与肺腺癌患者化疗效果的关系

目的 探讨血清肿瘤异常蛋白(TAP)与肺腺癌患者化疗效果的关系.方法 选取100例行术后辅助治疗或姑息治疗的肺腺癌患者(肺腺癌组)和50例健康体检者(对照组),比较治疗前两组的TAP水平以及不同病理分期肺腺癌患者的TAP水平.根据化疗效果将胰腺癌患者进行分组,分析不同组别患者治疗前后TAP水平的差异.结果 肺腺癌组的TAP水平和阳性率明显高于对照组(P﹤0.01);不同病理分期肺腺癌患者的TAP水平比较,差异有统计学意义(P﹤0.05),且病理分期越晚,TAP水平越高;完全缓解、部分缓解组患者治疗后TAP水平较本组治疗前下降,进展组患者治疗后TAP水平较本组治疗前升高,差异均有统计学意义(P﹤0.05);且患者的疗效越差,TAP水平越高.结论 肺腺癌患者的血清TAP水平明显升高,病情越重、预后越差的患者TAP水平越高,TAP可作为肺腺癌预后预测的重要指标.

Relationship between serum tumor abnormal protein and chemotherapy efficacy in patients with lung adenocarcinoma

Objective To explore the relationship between serum tumor abnormal protein (TAP) and chemotherapy efficacy in patients with lung adenocarcinoma. Method 100 cases of lung adenocarcinoma patients who had undergone postoperative adjuvant or palliative treatment (lung adenocarcinoma group) and 50 cases of healthy subjects (control group) were enrolled to compare the TAP levels prior to treatment between two groups and the TAP levels in patients be-tween different pathological stages of lung adenocarcinoma. The lung adenocarcinoma patients were grouped according to their chemotherapy efficacy to analyze the difference in TAP level before and after treatment. Result The TAP level and positive rate in lung adenocarcinoma group were both significantly higher than those in control group (P<0.01);the difference of TAP levels in patients with lung adenocarcinoma between different pathological stages were statistically sig-nificant (P<0.05), and higher TAP levels were associated with more advanced pathological stage. In complete response group and partial response group, TAP levels after treatment were lower than those before treatment. In progression group, TAP levels after treatment were higher than those before treatment, and the differences reached statistical signifi-cant (P<0.05);the worse the efficacy got, the higher the TAP level was. Conclusions The serum TAP levels in patients with lung adenocarcinoma increase significantly;TAP levels are higher in patients with more advanced disease and worse prognosis. TAP can be used as an important prognostic indicator for lung adenocarcinoma.