无症状性脑梗死认知障碍与Hcy和hs-CRP的关系

目的 探讨无症状性脑梗死患者认知功能障碍与hs-CRP和Hcy的关系.方法 对玉溪市中医医院心脑病科门诊和住院患者150例,行头颅CT和（或）MRI扫描,根据MMSE及CDT评分分为认知障碍SCI组、无认知障碍SCI组及正常对照组.利用Olympus AU2700全自动生化分析仪对3组患者分别测定Hcy和hs-CRP,运用SPSS对数据进行统计分析.结果 无症状性脑梗死患者认知功能障碍发病率较高,认知障碍SCI组的Hcy浓度明显高于非认知障碍SCI组和正常对照组,且非认知障碍SCI组的Hcy浓度明显高于正常对照组（P＜0.01）;认知障碍SCI组患者hs-CRP水平明显高于非认知障碍SCI组和正常对照组（P＜0.01）,且非认知障碍SCI组hs-CRP水平高于正常对照组（P＜0.05）.结论 无症状性脑梗死患者认知功能障碍的发生与Hcy升高关系密切,高同型半胱氨酸血症可能是其危险因素之一,超敏C反应蛋白与SCI认知障碍和脑梗死密切相关.

Cognitive Deficits of Silent Cerebral Infarction is Associated with Hcy and hs-CRP

Objective To investigate the relationship between cognitive deficits of Silent cerebral infarction with hs-CRP and Hcy.Methods 150 outpatients and inpatients with cardiovascular diseases in Yuxi City Hospital of traditional Chinese medicine,were divided into cognitive deficits in SCI group,non cognitive deficits in SCI group and normal control group,according to MMSE and CDT score by brain CT and （or） MRI scan.Hcy and hs-CRP of three groups of patients were determined by using Olympus AU2700 automatic biochemical analyzer,and statistically analyzed by using SPSS17.0.Results The incidence of cognitive deficits was higher in patients with silent cerebral infarction.The concentration of Hcy cognitive deficits in SCI group was significantly higher than that of non cognitive deficits in SCI group and normal control group,non cognitive deficits in SCI group was significantly higher than that of normal control group （P ＜ 0.01）.Cognitive deficits in patients with SCI group,hs-CRP levels were significantly higher than that of non cognitive deficits in SCI group and normal control group （P ＜ 0.01）,and non cognitive deficits in SCI hs-CRP level was higher than that of normal control group （P ＜ 0.05）.Conclusion Silent cerebral infarction cognitive deficits is closely related to the increase of Hcy,hyperhomocysteinemia may be one of the risk factors,high sensitive C reactive protein is closely related to SCI cognitive deficits and cerebral infarction.