| 盐酸沙格雷酯对血管系统作用的研究进展 |
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| 引用本文： | 王佐广,彭晓云,温绍君.盐酸沙格雷酯对血管系统作用的研究进展[J].中国新药杂志,2005,14(4):487-490. |
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| 作者姓名： | 王佐广 彭晓云 温绍君 |
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| 作者单位： | 1. 北京市心肺血管疾病研究所高血压研究室,北京,100029
2. 正大制药集团北京正大绿洲医药科技有限公司,北京,100176 |
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| 摘 要： | 盐酸沙格雷酯(sarpogrelate hydrochloride,安步乐克)是新上市的5-HT 2 受体阻滞剂,其可能通过维持血管内皮细胞完整、防止血管平滑肌细胞增殖等对血管相关疾病具有重要作用.综述近几年来安步乐克对血管系统作用方面的研究,并讨论其作用特点及可能的作用机制.
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| 关 键 词： | 盐酸沙格雷酯 受体阻滞剂 血管 |
| 文章编号： | 1003-3734(2005)04-0487-04 |
Research progress of sarpogrelate,a novel5-HT 2 receptor antagonist on vascular system |
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| Wang Zuo-guang,PENG Xiao-yun,Wen Shao-jun.Research progress of sarpogrelate,a novel5-HT 2 receptor antagonist on vascular system[J].Chinese Journal of New Drugs,2005,14(4):487-490. |
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| Authors: | Wang Zuo-guang PENG Xiao-yun Wen Shao-jun |
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| Abstract: | Sarpogrelate hydrochloride is a novel 5-HT_2 receptor antagonist, which inhibits the 5-HT induced platelet aggregation, vasoconstriction and vascular smooth muscle proliferation, and improves the microcirculation in coronary artery disease (CAD). Sarpogrelate has been found to have beneficial effects in cardiovascular diseases, such as peripheral vascular disease, restenosis after coronary stunting,pulmonary hypertension, and acute and chronic myocardial infarction. The paper is focused on potentials of sarpogrelate as an agent against vascular diseases together with its pharmacological mechanism. |
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| Keywords: | 5-HT2 |
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