FOXC1、FAT4及YAP1蛋白在上皮性卵巢癌组织表达水平及意义研究

目的 探讨FOXC1、FAT4及YAP1蛋白在上皮性卵巢癌组织表达水平及意义.方法 收集了72例上皮性卵巢癌组织标本进行研究,同时选取正常卵巢组织标本60例,采用免疫组化染色法检测FOXC1、FAT4及YAP1蛋白表达.结果 上皮性卵巢癌组织FOXC1蛋白阳性表达率为41.67％,明显低于正常卵巢组织(P<0.05),...

FOXC1,FAT4 and YAP1 Proteins in Epithelial Ovarian Cancer Tissues

Objective To investigate the expression level and significance of FOXC1,FAT4 and YAP1 proteins in epithelial ovarian cancer.Methods 72 specimens of epithelial ovarian cancer were selected and 60 specimens of normal ovarian tissue were selected,the expression of FOXC1,FAT4 and YAP1 protein were detected by immunohistochemical staining.Results The positive expression rate of FOXC1 protein in epithelial ovarian cancer was 41.67%,which was significantly lower than that of normal ovarian tissue(P<0.05),while the positive expression rates of FAT4 and YAP1 protein were 80.56%and 76.39%,which were significantly higher than those of normal ovarian tissue(P<0.05);The positive expression rates of FOXC1 protein in patients with stageⅢ,middle and low differentiation and lymph node metastasis were 14.29%,20.00%and 18.52%,which were significantly lower than those of stage I to II,high differentiation and no lymph node metastasis(P<0.05);The positive expression rates of FAT4 and YAP1 in patients with middle and low differentiation and lymph node metastasis were 95.00%and 100.00%,90.00%and 96.30%,which were significantly higher than those with high differentiation and no lymph node metastasis(P<0.05);The positive expression rate of YAP1 protein in stageⅢpatients was 100%,which was significantly higher than that in stageⅠandⅡpatients(P<0.05);FOXC1 protein were negatively correlated with FAT4 and YAP1 protein(γs=-0.297 and-0.294,P<0.05),and FAT4 protein was positively correlated with YAP1 protein(γs=0.471,P<0.05).Conclusion The expression of FOXC1 protein in epithelial ovarian cancer tissue is low,and the expression of FAT4 and YAP1 protein are highly expressed,there has a certain relationship with clinicopathological features,is worth further study.