宫颈癌术后感染状况及其与Caspase-1、IL-1β表达情况的相关性

目的 探讨宫颈癌术后感染状况及其与半胱氨酸天门冬氨酸蛋白水解酶-1(Caspase-1)和白细胞介素-1β(IL-1β)表达的相关性.方法 选取宫颈癌手术患者共297例,观察术后感染率,并对感染患者感染病原菌分布检测.同时对所有患者术后组织样本内Caspase-1、IL-1β表达情况进行检测.结果 手术后有15％的患者...

Postoperative Infection and Expression of Caspase-1 and IL-1beta in Cervical Cancer

Objective To investigate the effect of infection after cervical cancer surgery on the expression of caspase-1 and interleukin-1beta(IL-1beta)in cervical cancer samples,and to provide reference for the diagnosis and treatment of cervical cancer infection after surgery.Methods 297 patients with cervical cancer treated were selected to observe the infection rate and detect the distribution of pathogenic bacteria in the infected patients.At the same time,the expression of Caspase-1 and IL-1beta in tissue samples of all patients were detected.Results Postoperative infection occurred in 15% of patients after operation.Gram-negative bacteria accounted for the main part of pathogenic bacteria(p<0.05).At the same time,the expression of Caspase-1 and IL-1beta in serum of patients with post-operative infection was significantly higher than that of patients without post-operative infection(P<0.05).Infection group.Conclusion Postoperative infection of cervical cancer is mainly caused by Gram-negative bacteria,so the necessary antimicrobial treatment should be carried out after operation.At the same time,the positive detection of serum Caspase-1 and IL-1beta expression after operation can prevent and treat the occurrence of infection in time.