钩端螺旋体外膜菌苗流行病学效果研究

目的：证实钩端螺旋体外膜菌苗的安全性和免疫效果。方法：在湖北省荆州市和石首市现场接种钩端螺旋体外膜菌80000人份，观察48h内体温、局部红肿等副反应和一年内接种钩端螺旋体外膜菌苗者发病情况，同时设对照组。结果：所有钩端螺旋体外膜菌苗接种者未见严重副反应和异常反应，仅2例菌苗接种者有低热和局部红肿，48h后消失，安全性良好。接种组发生黄疸出血群钩端螺旋体病人2例，对照组发生黄疸出血群钩端螺旋体病人47例，黄疸出血群钩端螺旋体外膜菌苗保护效果95.57％，95％可信限为85.43％－98.20％；对照组发生七日热群钩,端螺旋体病人15例，七日热群钩端螺旋体外膜菌苗有效率100.00％，95％可信限下限77.08％。结论：钩端螺旋体外膜菌苗安全性良好，接种与疫区流行菌群一致的钩端螺旋体外膜菌苗，可以取得良好的免疫保护效果。

Epidemiological observation on effect of Leptospiral outer membrane vaccine

Objective To study the safety and effect of Leptospiral outer membrane vaccine. Methods Eighty thousands dosages of Leptospiral outer membrane vaccine were vaccinated in Jingzhou and Shishou city Hubei prevince. Temperaure, side effects such as Local edema with in 48 hours as well as the incidence of Leptospirsis within a year among those were vaccinated and unvaccinated were observed. Results (1)No any severe side effect and abnormal reaction, was found, only 2 case suffered from slight fever and local edema which receded in 48 hrs. (2) Effects of Leptospiral outer membrane vaccine were as follows: 2 cases were attacked by lcterohaemorrhagiae in vaccination group and 47 cases in control group, so the protection rate 95.57 % and confidence interval (CI) was 85.43 % 98.20 %. Fifteen hebdomadis cases were found in control group. The protection rate of this vaccine reached 100.00 %, CI 77.08 % 100.00 %. Conclusion Safty and protective effect were well showed when type of bacteria was concordant with that in vaccination district.