恶性淋巴瘤患者NK细胞活性及T细胞亚群的研究

目的：探讨恶性淋巴瘤患者ＮＫ细胞活性及Ｔ细胞亚群在治疗后的变化。方法：运用ＭＴＴ和ＡＰＡＡＰ法分别检测４６例恶性淋巴瘤患者的ＮＫ细胞活性及Ｔ细胞亚群。结果：恶性淋巴瘤患者ＮＫ细胞活性及Ｔ细胞亚群均显著降低，而且治疗后均有所回升，但仍低于正常；而在治疗后２ａ未复发者，ＮＫ细胞活性及Ｔ细胞亚群与正常人接近。结论：ＮＫ细胞活性及Ｔ细胞亚群的测定对恶性淋巴瘤病情的监测、治疗的指导及预后的评估有重要意义。

STUDY ON NK CELL ACTIVITY AND T-LYMPHOCYTE SUBCATEGORIES IN PATIENTS WITH MALIGNANT LYMPHOMA

Objective:To study the difference of NK cell activity and T lymphocyte subcategories before and after treatment.Methods:Fourty six malignant lymphoma patients were served as subjects and thirty two health persons as control.NK activity was measured with MTT method.T lymphocyte were measured with method of APAAP.Results:NK cell activity and T lymphocyte subcategories in patients with malignant lymphoma decreased markedly.After treatment,It shows improvement,but was lower than controls.After two years treatment with CR,NK cell activity and T lymphocyte subcategories was unchanged with control.Conclusion:It is of very important clinical significance in therapy judgement of curative effect and evaluation of prognosis.