放置不同材料IUD_s后兔子宫内膜纤溶活性的改变

本文介绍兔一侧子宫内分别放置铜、钢、磁性物质及铜加6-氨基己酸(EACA)制成的宫内节育器(IUD),观察子宫内膜的纤溶变化。发现实验侧纤溶活性均明显高于对照侧,以铜为最明显。比较对照试验,铜IUD侧纤溶活性高于钢及磁(P<0.05),钢与磁之间无差异(P>0.05)。置含EACA铜IUD组分别于置器后7,14,28天后观察纤溶活性。7及14天组实验侧与对照侧纤溶活性无差异。28天后实验侧明显高于对照侧。用含EACA铜与无EACA的铜IUD进行对比,7天组实验侧纤溶活性低于对照侧(0.05

HISTOCHEMIC AL CHANGES IN ENDOMETRI AL FIBROLYTIC

The histochemical changes of endometrial fibrinolytic activity were observed in rabbitsOne horn of the uterus was put in IUDs made of different materials (steel, copper,magnet and EACA-copper). It was found that the endometrial fibrinolytic activity in theexperimental horns was significantly higher than controls, and the effect was thehighest with the copper IUD. In the contrasted groups (copper vs steel, copper vs magnet,steel vs magnet), the endometrial fibrinolytic activity induced by the copper IUD was thehighest (P<0.05), while there was no significant difference between that of steel and magnet(P>0.05). In the EACA- copper IUD groups, the results were also observed on days 7, 14 and28 after insertion of the devices. There was no difference in fibrinolytic activity between theexperimental horns and the controls in 7 and 14 days groups, but it was significantly higherthan the controls in 28 days group In the contrasted groups of the EACA-copper IUDand copper IUD the endometrial fibrinolytic activity of the former was lower than that ofthe latter in 7 days group (0.05