2型糖尿病患者血清胱抑素C与冠心病的关系

目的探讨2型糖尿病患者血清胱抑素C（CysC）与冠心病的相关性。方法行冠脉造影检查的106例2型糖尿病患者，根据有无并发冠心病分为糖尿病合并冠心病组（36例）和糖尿病无冠心病组（70例），检测空腹血糖、餐后2小时血糖、糖化血红蛋白、三酰甘油、胆固醇、血肌酐、高敏C反应蛋白、CysC、同型半胱氨酸等。分析冠心病与CysC的相关性，并用二元Logistic回归方法分析CysC和其他相关因素与冠心病之间的相关性。结果糖尿病合并冠心病组CysC含量明显高于无冠心病组（P〈0．001），应用二元Logistic回归方法进行分析，发现CysC、高敏C反应蛋白、餐后2小时血糖、收缩压、体重指数与冠心病相关。结论CysC是2型糖尿病患者发生冠心病的独立危险因素，检测CysC是预测2型糖尿病患者冠心病发病的有意义的指标。

The relationship between serum cystatin C and coronary heart disease in type 2 diabetic patients

Objective To investigate the relationship between serum cystatin C （CysC） and coronary heart disease in patients with type 2 diabetes. Methods 106 type 2 diabetic patients underwent coronary angiography were recruited （36 cases with coronary heart disease, 70 cases without coronary heart disease）. The serum levels of fasting plasma glucose （ FPG）, 2 hPG, HbA 1 c, triglycerides （ TG ）, cholesterol （TC）, creatinine（Scr）, high-sensitivity C-reactive protein （ hsCRP）, CysC, and homocysteine （Hcy） were detected and analyzed among the two groups. Results Diabetic patients with coronary heart disease had significantly higher level of cystatin C（ P 〈 0. 001 ）in comparison to the group without coronary heart dis- ease. Follow-up of the application of Logistic regression analysis found that higher cystatin C, hsCRP, 2hPG, SBP and BMI were directly associated with a higher risk of coronary heart disease. Conclusions Elevated cystatin C levels were independently associated with coronary heart disease in type 2 diabetic patients,and cystatin C was a strong predictor for the risk of coronary heart disease.