| 11个单环β-内酰胺类化合物的合成及其抗菌活性初探 |
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| 引用本文： | 王建伟,黄娟,李恒光,张淑华. 11个单环β-内酰胺类化合物的合成及其抗菌活性初探[J]. 中国抗生素杂志, 2003, 28(8): 459-462 |
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| 作者姓名： | 王建伟 黄娟 李恒光 张淑华 |
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| 作者单位： | 1. 四川抗菌素工业研究所,成都,610051
2. 四川大学药学院,成都,610041 |
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| 摘 要： | 根据单环β—内酰胺类化合物定量构效关系研究的结果提示，以N-苄基-3(S)-邻苯二甲酰亚胺基-4(S)-[4(S)-2，2-二甲基-1，3二氧环戊-4-基]-2-氧吖丁啶为原料，设计合成了11个新的单环β—内酰胺类化合物，其结构经MS、^1H—NMR或IR所确证，并测定了它们的体外抗菌活性，结果表明，它们均有抗菌作用，但抗菌活性低于对照品。
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| 关 键 词： | 单环β—内酰胺 合成 抗菌活性 |
| 文章编号： | 1001-8689(2003)08-0459-04 |
| 修稿时间： | 2003-04-07 |
Synthesis of 11 monobactams and their antibacterial activity |
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| Wang Jian-wei ,Huang Juan ,Li Heng-guang and Zhang Shu-hua. Synthesis of 11 monobactams and their antibacterial activity[J]. Chinese Journal of Antibiotics, 2003, 28(8): 459-462 |
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| Authors: | Wang Jian-wei Huang Juan Li Heng-guang Zhang Shu-hua |
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| Affiliation: | Wang Jian-wei 1,Huang Juan 2,Li Heng-guang 1 and Zhang Shu-hua 1 |
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| Abstract: | Based on the result of quantitative structure activity relationship (QSAR) which was studied among monobactams, 11 new monobactams were designed and synthesized from N-benzyl-3(S)-phthalimido-4(S)-[4(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-oxo-azetidine, their structure had been determined by 1H-NMR or IR and MS, and in vitroantibacterial activities of these compounds were tested. Results showed that they have lower activities than those of control compounds. |
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| Keywords: | Monobactams Synthesis Antibacterial activity |
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