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脂肪来源细胞在缺血性心脏病中的应用
引用本文:杨华,沈珠军. 脂肪来源细胞在缺血性心脏病中的应用[J]. 基础医学与临床, 2010, 30(11): 1226-1229
作者姓名:杨华  沈珠军
作者单位:中国医学科学院,北京协和医学院,北京协和医院,心内科,北京,100730
摘    要:
 脂肪来源细胞(褐色脂肪来源细胞、脂肪干细胞和去分化脂肪细胞)可分化成心肌样细胞,移植后可改善心梗后心功能,降低心室重塑,有可能成为最有潜力的治疗缺血性心脏病的干细胞来源。

关 键 词:脂肪组织  脂肪干细胞  去分化脂肪细胞  缺血性心脏病  心力衰竭  
收稿时间:2010-01-25
修稿时间:2010-03-07

Application of adipose tissue-derived cells in ischemic heart disease
YANG Hua,SHEN Zhu-jun. Application of adipose tissue-derived cells in ischemic heart disease[J]. Basic Medical Sciences and Clinics, 2010, 30(11): 1226-1229
Authors:YANG Hua  SHEN Zhu-jun
Abstract:
Ischemic heart disease leading to heart failure seriously affects the quality of patients'life. Stem cell transplantation has been proposed to be a promising therapy for ischemic heart disease. Adipose-tissue derived stem cells (ADSC)and Dedifferentiated FAT (DFAT) cells are able to differentiate into multiple cell lineages including cardiac myocytes. Transplantation of adipose-derived cells after myocardial infarction significantly improves heart function, reduces ventricular remolding. Hence, adipose-derived cells are emerging as a new sourse of adult stem cells for cardiovascular repair.
Keywords:Adipose Tissue  Adipose-Tissue Derived Stem Cell  Dedifferentiated Adipocyte  Ischemic Heart Disease  Heart Failure
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