| Alzheimer 病和血管性痴呆事件相关电位的对照研究 |
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| 引用本文： | 王晓红,解恒革,刘凤荣,王鲁宁.Alzheimer 病和血管性痴呆事件相关电位的对照研究[J].中国组织工程研究与临床康复,2001,5(3):47-49. |
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| 作者姓名： | 王晓红 解恒革 刘凤荣 王鲁宁 |
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| 作者单位： | 解放军总医院, |
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| 基金项目： | 军队“九五”课题(98M139)和国家卫生部“九五”攻关课题（96－906－05－07)资助 |
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| 摘 要： | 目的探讨事件相关电位P300在Alzheimer病(AD)和血管性痴呆(VD)鉴别诊断中的作用。方法对年龄匹配的AD患者30例，VD患者16例，正常老年人对照组41例进行P300检查。结果与正常老年人比较，AD和VD患者N1、N2、P3潜伏期均明显延长，AD和VD组比较，AD患者P3潜伏期显著延长，而P3波幅显著降低。判别分析表明，P3潜伏期鉴别AD的敏感性为70％，特异性为75％，总准确率为72.5％(P=0.002)。结论由于病理基础不同，AD和VD患者P300也存在差异，此差异在痴呆的辅助鉴别诊断中有一定意义。
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| 关 键 词： | 阿尔茨海默病 血管性痴呆 事件相关电位 |
| 文章编号： | 007－5496(2001)02－0047－02 |
| 修稿时间： | 2000年9月4日 |
A comparison study of event-related potentials in Alzheimer disease and vascular dementia |
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| WANG Xiao hong,XIE Heng ge,LIU Feng rong,et al..A comparison study of event-related potentials in Alzheimer disease and vascular dementia[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2001,5(3):47-49. |
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| Authors: | WANG Xiao hong XIE Heng ge LIU Feng rong |
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| Institution: | WANG Xiao hong,XIE Heng ge,LIU Feng rong,et al. Chinese PLA General Hospital,Beijing 100853,China |
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| Abstract: | Objective To investigate the effect of event-related potentials in the differential diagnosis between Alzheimer disease and vascular dementia.Methods Event-related potentials were performed in 30 patients with AD,16 with VD and 41 normal controls. Results The latencies of N1,N2,P3 were significantly prolonged in AD and VD group,when compared with normal controls.AD patients had a significant longer P3 latency and lower P3 amplitude than VD patients.The sensitivity and specificity of P3 latency in discriminant function analysis between AD and VD were 70％ and 75％ ,respectively.Conclusion The difference of P300 between AD and VD,which was related with their neuropathological basis,may be used if necessary. |
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| Keywords: | Alzherimer disease vascular dementia event-related potentials |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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