Decreased maternal circulating hepatocyte growth factor (HGF) concentrations in pregnancies with small for gestational age infants |
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| Authors: | Aoki, Showa Hata, Toshiyuki Manabe, Atsushi Miyazaki, Kohji |
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| Affiliation: | 1 Department of Obstetrics and Gynecology, Shimane Medical University, Izumo 693-0027, Japan 2 Department of Perinato-Gynecology, Kagawa Medical University, 1750-1 Ikenobe, Miki, Kagawa 761-0793, Japan |
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| Abstract: | ![]()
Our purpose was to evaluate whether maternal and fetal hepatocytegrowth factor (HGF) concentrations in pregnancies with smallfor gestational age (SGA) infants are different from those inpregnancies with appropriate for gestational age (AGA) infants.Maternal and fetal circulating HGF concentrations were comparedbetween 55 pregnancies with AGA infants and 16 pregnancies withSGA infants at birth. HGF concentrations were measured frommaternal and cord venous blood samples using an enzyme-linkedimmunosorbent assay. Umbilical artery blood pH and oxidativepressure (PO2) were also measured. Maternal circulating HGFconcentrations (0.60 ± 0.35 ng/ml) in pregnancies withSGA infants were significantly lower than those (0.91 ±0.44 ng/ml) in pregnancies with AGA infants (P = 0.012). Therewere no significant differences in fetal circulating HGF concentrationsbetween both groups. No significant differences in umbilicalartery blood pH and PO2 were found between both groups. Theseresults suggest that the maternal serum circulating HGF concentrationhas a significant role in fetal growth during pregnancy. |
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| Keywords: | appropriate for gestational age infant/fetal growth/hepatocyte growth factor/small for gestational age infant |
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