| 砷致癌动物模型研究现状 |
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| 引用本文： | 安艳.砷致癌动物模型研究现状[J].卫生研究,2006,35(6):814-818. |
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| 作者姓名： | 安艳 |
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| 作者单位： | 山东省医学科学院放射医学研究所,济南,250062 |
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| 摘 要： | 人类流行病学资料显示,长期暴露于砷化合物可以导致人类皮肤、肺、膀胱、肝和肾脏的癌症。近来报道指出,砷在小鼠和大鼠的相应器官也可诱发促癌或完全致癌作用,给予p53+/-和K6/ODC转基因小鼠无机砷的甲基化代谢产物二甲基胂酸(DMA)或亚砷酸盐,对转基因小鼠的皮肤或膀胱有一定程度的致癌、联合致癌或促癌作用。由于到目前为止尚无无机砷化合物致癌的动物模型,致使其致癌机制的研究一直滞后,所以大量研究人员致力于野生型和转基因动物的砷致癌动物模型研究,本文就这一方面的研究进展做一综述。
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| 关 键 词： | 砷致癌作用 动物模型 甲基化砷 转基因小鼠 |
| 文章编号： | 1000-8020（2006）06-0814-04 |
| 收稿时间： | 2005-12-12 |
| 修稿时间： | 2005年12月12 |
Current progress in animal models of arsenic carcinogenesis |
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| An Yan.Current progress in animal models of arsenic carcinogenesis[J].Journal of Hygiene Research,2006,35(6):814-818. |
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| Authors: | An Yan |
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| Institution: | Department of Radiation Effect, Institute of Radiation Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China |
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| Abstract: | Recent advances in our knowledge of arsenic carcinogenesis include the development of rat or mouse models for all human organs in which inorganic arsenic is known to cause cancer-skin,lung,urinary bladder,liver,and kidney.Tumors can be produced from either promotion of carcinogenesis protocols or from complete carcinogenesis protocols.Experiments with p53+/-and K6/ODC transgenic mice administered dimethylarsinic acid(DMA) or arsenite have shown some degree of carcinogenic,cocarcinogenic,or promotional activity in skin or bladder.At present,with the possible exception of skin,the arsenic carcinogenesis models in wild-type animals are more highly developed than in transgenic mice.In this review,animal models of arsenic carcinogenesis are presented and discussed animal models of DMA carcinogenesis,transgenic animal models of arsenic carcinogenesis,and methylated metabolites of arsenic. |
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| Keywords: | arsenic carcinogenesis animal models methylated arsenic transgenic mice |
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