| 兔激素性股骨头坏死软骨与软骨下骨组织损伤的实验研究 |
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| 引用本文： | 程少华,赵伦华,汤显斌,王珏. 兔激素性股骨头坏死软骨与软骨下骨组织损伤的实验研究[J]. 郧阳医学院学报, 2010, 29(1): 45-47,F0004 |
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| 作者姓名： | 程少华 赵伦华 汤显斌 王珏 |
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| 作者单位： | 程少华(郧阳医学院附属太和医院骨科,湖北 十堰,442000);赵伦华,汤显斌,王珏(郧阳医学院附属太和医院病理科,湖北 十堰,442000) |
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| 基金项目： | 湖北省教育厅重点项目 |
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| 摘 要： | 目的:通过分析早期激素性股骨头坏死(SANFH)软骨与软骨下骨组织损伤的相互关系以探讨其发病机制。方法:42只日本大耳白兔通过大剂量注射醋酸泼尼松龙制作激素性股骨头坏死SANFH模型,第2、6周观察其股骨头软骨、软骨下区骨组织、软骨下区血管的变化。结果:第2周时软骨下区骨组织部分陷窝空虚,呈区域性分布;第6周骨小梁稀疏、变细,出现微骨折。软骨下区小动脉结构破坏,静脉及毛细血管扩张、淤血。造血组织减少,肥大细胞增多,基质水肿、出血。结论:早期SANFH中软骨深层细胞损伤与软骨下骨组织坏死可能同时形成,其在SANFH发病过程中可能起到重要作用。
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| 关 键 词： | 股骨头坏死 激素 软骨下骨 软骨 |
Study on Tissue Injury of Cartilage and Subchondral Bone in Rabbits Steroid-induced Necrosis of Femoral Head |
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| CHENG Shao-hua,ZHAO Lun-hua,TANG Xian-bin,WANG Jue. Study on Tissue Injury of Cartilage and Subchondral Bone in Rabbits Steroid-induced Necrosis of Femoral Head[J]. Journal of Yunyang Medical College, 2010, 29(1): 45-47,F0004 |
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| Authors: | CHENG Shao-hua ZHAO Lun-hua TANG Xian-bin WANG Jue |
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| Affiliation: | CHENG Shao-hua1,ZHAO Lun-hua2,TANG Xian-bin2,WANG Jue2 (1Department of Orthopaedics,2Department of Pathology,Taihe Hospital,Yunyang Medical College,Shiyan,Hubei 442000,China) |
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| Abstract: | Objective To explore the pathogenesis of steroid-induced avascular necrosis of femoral head(SANFH) according to analyze the relationship between articular cartilage and subchondral bone tissue injury in early stage.Methods The SANFH model was prepared with massive dose of prednisolone acetate injection in 42 mature Japanese rabbits.The histopathological change in articular cartilage,subchondral bone and blood vessels subcricoid region were observed at the end of second and sixth week.Results Empty bone lacu... |
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| Keywords: | Femoral head necrosis Hormone Subchondral bone Cartilage |
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